Signs of Hyperinflation and Ventilation Heterogeneity in Individuals With Severe Alpha-1-Antitrypsin Deficiency at the Age of 42.

Georg Rüdiger Schramm, Per Wollmer, Eeva Piitulainen, Suneela Zaigham, Hanan Tanash

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Article in International journal of chronic obstructive pulmonary disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Georg Rüdiger SchrammDepartment of Internal Medicine, Skåne University Hospital, Malmö, Sweden, Lund University, Lund, Sweden.ORCID 0000-0002-8069-1539

Per WollmerDepartment of Medical Imaging and Physiology, Skåne University Hospital, Malmö, Sweden, Lund University, Lund, Sweden.

Eeva PiitulainenDepartment of Internal Medicine, Skåne University Hospital, Malmö, Sweden, Lund University, Lund, Sweden.

Suneela ZaighamDepartment of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-9132-5665

Hanan TanashDepartment of Internal Medicine, Skåne University Hospital, Malmö, Sweden, Lund University, Lund, Sweden.

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6 · The paper itself

Abstract

Background: Severe alpha-1-antitrypsin deficiency (AATD) is a known risk factor for early development of emphysema and COPD. By the Swedish national screening program within the years 1972-74 a cohort of individuals with severe AATD (PiZZ) was identified and regularly followed up. The aim of this study was to investigate alveolar volume (V Methods: All study participants underwent pulmonary function tests (PFT) including dynamic spirometry and total lung capacity (TLC), residual volume (RV), functional residual capacity (FRC) and alveolar volume (V Results: Fifty-six PiZZ and 66 PiMM individuals participated in the study. The PiZZ individuals had a significantly lower V Conclusion: At the age of 42 the PiZZ ever-smokers have signs of hyperinflation and ventilation heterogeneity.

Indexed as

alpha 1-Antitrypsin DeficiencyLungPulmonary Disease, Chronic ObstructivePulmonary EmphysemaPulmonary VentilationAdultAge FactorsCase-Control StudiesFemaleHumansMaleMiddle AgedPhenotypePredictive Value of TestsQuality of LifeRegistriesalpha-1-antitrypsin-deficiencyalveolar volumehyperinflationsmoking

Identifiers

PMID40066198

DOI10.2147/COPD.S486575

PMCPMC11890972

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