Evidence map›Paper›PMID 40065951›Full record

ArticleIndian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India2025

Impact of Induction Chemotherapy Before Radical Chemoradiation in Oral Cavity Squamous Cell Carcinoma: A Tertiary Centre Experience.

Sauharda Lohani, Gerim Prasai, Sarthak Tandon, Parveen Ahlawat, Varghese Antony, Akash R Bellige, Vibhor Patodi, Shaifali Mahajan, Preetha Umesh, Apoorva Nayak and 1 more

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Article in Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sauharda LohaniDepartment of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector-5, Rohini, New Delhi, 110085 India.
Gerim PrasaiDepartment of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector-5, Rohini, New Delhi, 110085 India.
Sarthak TandonDepartment of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector-5, Rohini, New Delhi, 110085 India.
Parveen AhlawatDepartment of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector-5, Rohini, New Delhi, 110085 India.
Varghese AntonyDepartment of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector-5, Rohini, New Delhi, 110085 India.
Akash R BelligeDepartment of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector-5, Rohini, New Delhi, 110085 India.
Vibhor PatodiDepartment of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector-5, Rohini, New Delhi, 110085 India.
Shaifali MahajanDepartment of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector-5, Rohini, New Delhi, 110085 India.
Preetha UmeshDepartment of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector-5, Rohini, New Delhi, 110085 India.
Apoorva NayakDepartment of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector-5, Rohini, New Delhi, 110085 India.
Munish GairolaDepartment of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, Sector-5, Rohini, New Delhi, 110085 India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advanced Oral Cavity Squamous Cell Carcinoma (OSCC) poses challenges for upfront resection. While surgery followed by adjuvant treatment is standard, induction chemotherapy is explored for better resectability and organ preservation. Its efficacy in unresectable cases is still uncertain and yet to be proven. A retrospective study was done at our institute by reviewing the institutional database from January 2018 to December 2020, where patients with biopsy proven OSCC who were considered unresectable disease but treated with curative intention recruited. All the patients recruited were divided into two cohorts: Radical CCRT (Arm A) or Induction Chemotherapy (IC) followed by Chemo Radiotherapy (CCRT) (Arm B) were evaluated. The patients were analyzed for progression free survival (PFS) and Overall Survival (OS). One hundred and eighty (180) patients of locally advanced unresectable OSCC were treated with curative intent. However, data of 22 (12%) patients were excluded because of incomplete data in the database. Of remaining 158 patients, 120 (76%) and 38 (24%) were divided into arm A and B, respectively. Baseline characteristics were statistically similar in both arms except for sub site distribution with higher percentage of buccal mucosa primary [25.8% vs 42.1% in arm A vs. B respectively,

Indexed as

ChemoradiationHead and neckInduction chemotherapyOral cavityUnresectable oral cancer

Identifiers

PMID40065951
PMCPMC11890703

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.