ReviewCureus2025
Vitamin E (α-Tocopherol): Emerging Clinical Role and Adverse Risks of Supplementation in Adults.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Association Between Serum α-Tocopherol and Pathogenesis of Multiple Sclerosis: A Systematic Review and Meta-Analysis of Case-Control Studies.BioMed research international · 2026Pooled it
- Pharmacological interventions to prevent cardiotoxicity in patients undergoing anthracycline-based chemotherapy: a network meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- Vitamin E dosing study (VEDS) in patients with metabolic dysfunction-associated steatotic liver disease with elevated aminotransferases: A multicenter, randomized, placebo-controlled trial.Hepatology (Baltimore, Md.) · 2026Article
- Association between oxidative balance score and cardiometabolic multimorbidity: differential mortality, mediation mechanisms, and machine learning insights.Journal of translational medicine · 2026Article
- Efficacy of Vitamin E Supplementation During Pregnancy on the Vitamin E Nutritional Status of the Mother-Child Dyad: A Systematic Review and Meta-Analysis of Randomized Controlled Trial.Food science & nutrition · 2026Review
- Topical 915-3985 MHz Microwave Sweep-Assisted Retention of Nanoemulsified α-Tocopherol for Dermatitis Treatment.AAPS PharmSciTech · 2026Article
- Edible Bird's Nest as a Multi-Component Functional Food for Brain Aging: From Single-Bioactive Actions to Network-Regulatory Mechanisms.Nutrients · 2026Review
- Next-Generation Antioxidants in Cardiovascular Disease: Mechanistic Insights and Emerging Therapeutic Strategies.Antioxidants (Basel, Switzerland) · 2026Review
- Vitamin E Protects Against Gestational Deep Vein Thrombosis: The Role of Inhibiting Endothelial Ferroptosis.Drug design, development and therapy · 2026Article
- Micronutrient balance and brain function: neuropsychological, metabolic, and clinical interactions.Frontiers in molecular biosciences · 2026Review
- The role of nutrition and multimodal lifestyle interventions in Alzheimer's prevention and management: a mini-review.Frontiers in nutrition · 2026Review
- Significance of Vitamins A and E in Cancer Progression and Prevention.International journal of molecular sciences · 2025Review
- The Vicious Circle of Metabolic Dysfunction-Associated Steatotic Liver Disease When Micronutrient Deficiency Drives Microbial Imbalance and Liver Injury.Life (Basel, Switzerland) · 2025Review
- Review
- Effect of Dietary PUFAs and Antioxidants on Antioxidant and Anti-Inflammatory Functions of HDL in a Cohort of Women.Antioxidants (Basel, Switzerland) · 2025Article
- Effect of Various Types of Heat Processing on the Content and Retention of Fat-Soluble Vitamins and Cholesterol in Goose Breast Meat.Foods (Basel, Switzerland) · 2025Article
- Chronic Inflammation and Immune Dysregulation in Metabolic-Dysfunction-Associated Steatotic Liver Disease Progression: From Steatosis to Hepatocellular Carcinoma.Biomedicines · 2025Review
- Exploring motivations, information behavior, perceptions, and intentions among dietary supplement users: a cross-sectional survey study in Germany.Frontiers in nutrition · 2025Article
- Nutritional strategies against dementia in rural populations.Frontiers in nutrition · 2025Review
- Linking oxidative stress biomarkers to disease progression and antioxidant therapy in hypertension and diabetes mellitus.Frontiers in molecular biosciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vitamin E, primarily in its active form α-tocopherol, is a well-known antioxidant that protects cells from oxidative stress and free radical damage. It plays an essential role in maintaining cellular integrity and supporting immune function, making Vitamin E a widely popular and easily accessible dietary supplement for overall health and wellness. However, high-dose Vitamin E supplementation has become a concern related to potential risks. The scientific research surrounding the safety and efficacy of Vitamin E is complex yet emphasizes a balance in the use of Vitamin E supplementation. Excessive or high-dose supplementation causes a shift in this balance, as Vitamin E's beneficial antioxidant properties are outweighed by harmful interference in normal cellular processes such as immunity, cell growth, and oxidative stress. An additional complication involves Vitamin E's anticoagulant effects, which have been shown to amplify the risk of bleeding when high-dose supplementation is combined with blood thinners such as warfarin and aspirin. Studies have linked high-dose Vitamin E supplementation to adverse outcomes, including enhanced risks of all-cause mortality, hemorrhagic stroke, cardiovascular events, and certain cancers. These risks are particularly significant for individuals with pre-existing health conditions such as heart failure, coagulation disorders, or a history of stroke. The potential risk of adverse side effects emphasizes the need for further research into high-dose Vitamin E supplementation. This review will provide a comprehensive analysis of Vitamin E's multifaceted role in health and physiology, focusing on navigating the balance between potential benefits and risks in supplementation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.