ArticleFrontiers in oral health2025
The tumor coagulome as a potential biological determinant of postsurgical recurrence of oral squamous cell carcinoma.
Article in Frontiers in oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: The tumor coagulome is an intrinsic characteristic of human tumors and a key determinant of cancer-associated thrombosis (CAT). Oral Squamous Cell Carcinoma (OSCC) establish a local procoagulant state that contributes to a broad range of vascular complications, and potentially also to tumor progression. Recent clinical studies suggest that biomarkers of coagulation might be of interest for predicting postsurgical recurrence of OSCC, but it remains unclear whether specific properties of the coagulome of OSCC are conducive to postsurgical recurrence. We examined this possibility using transcriptomic analyses of OSCC. Materials and methods: Using bulk RNA-seq data from TCGA and other sources, we explored the link between the coagulome ( Results: We identified seven coagulation-related genes, either positively ( Conclusion: Our observations suggest that active coagulation shapes the oncological outcome of surgery. Analyzing the tumor procoagulant status might help predict postsurgical recurrence of OSCC.
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