Evidence map›Paper›PMID 40065816›Full record

ArticleRSC advances2025

Process optimizations for the synthesis of an intermediate of dydrogesterone.

Zhongyue Wang, Yuan Wang, Shaoxiong Jing, Xiangjian Huang, Hucheng Wu, Yingquan Yang, Jian Song, Bao Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhongyue WangTianjin University, School of Chemical Engineering and Technology Tianjin China yue7946801@tju.edu.cn baozhang@tju.edu.cn songjian@tju.edu.cn.
Yuan WangTianjin University, School of Chemical Engineering and Technology Tianjin China yue7946801@tju.edu.cn baozhang@tju.edu.cn songjian@tju.edu.cn.
Shaoxiong JingTianjin University, School of Chemical Engineering and Technology Tianjin China yue7946801@tju.edu.cn baozhang@tju.edu.cn songjian@tju.edu.cn.
Xiangjian HuangSuzhou Entai New Materials Technology Company Suzhou China huangxj0703@sina.com 375831573@qq.com.
Hucheng WuSuzhou Entai New Materials Technology Company Suzhou China huangxj0703@sina.com 375831573@qq.com.
Yingquan YangSuzhou Entai New Materials Technology Company Suzhou China huangxj0703@sina.com 375831573@qq.com.
Jian SongTianjin University, School of Chemical Engineering and Technology Tianjin China yue7946801@tju.edu.cn baozhang@tju.edu.cn songjian@tju.edu.cn.
Bao ZhangTianjin University, School of Chemical Engineering and Technology Tianjin China yue7946801@tju.edu.cn baozhang@tju.edu.cn songjian@tju.edu.cn.ORCID https://orcid.org/0000-0003-4846-0594

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dydrogesterone (DG) is a potent progesterone drug that can be used to treat almost all progesterone-deficiency in women. However, there are few reports on DG process studies, and the by-products are unclear, which make the process optimization challenging. In this paper, we report the process optimization studies for the synthesis of 9α,10β-pregest-5,7-diene-3,20-diethylene glycol ketone (1), an intermediate of DG. Starting from the natural raw progesterone, the intermediate 1 was synthesised

Identifiers

PMID40065816
PMCPMC11891995

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.