ArticleRespirology case reports2025
Multiple Myeloma Complicated With Bronchiolitis Obliterans Syndrome After Allogeneic Haematopoietic Stem Cell Transplantation and Subsequently Underwent Lung Transplantation Successfully: A Case Report.
Article in Respirology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for multiple myeloma; however, the development of chronic graft-versus-host disease remains a significant challenge. Bronchiolitis obliterans syndrome (BOS) is one of the complications. Even with available medications for treatment, the prognosis of BOS remains poor. We present a 32-year-old female with multiple myeloma experienced BOS 6 months after allo-HSCT. Even with medical treatment, her clinical condition and pulmonary function was deteriorating. Based on the indication of a BODE (Body-mass index, Obstruction, Dyspnoea and Exercise) index of 7, she underwent bilateral lung transplantation 33 months after allo-HSCT. Three months post-operation, there was a significant improvement in pulmonary function. After approximately 5 years of follow-up, her lung function remains stable, and she is able to work and live a normal life. Lung transplantation may be an effective therapeutic strategy for BOS developed after allo-HSCT.
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