Evidence map›Paper›PMID 40065721›Full record

ArticleActa biochimica et biophysica Sinica2025

HDAC11 in ovarian granulosa cells coordinates LH in the maturation of oocytes in Tan sheep.

Jiaqi Shi, Donghuan Lv, Yaxiu Xu, Xiangyan Wang, Zhipeng Qi, Yujie Yan, Jinghua Wang, Hongyuan Song, Hui Yang, Luguo Jin and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biochimica et biophysica Sinica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The histone deacetylase family in health and disease.Signal transduction and targeted therapy · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jiaqi ShiKey Laboratory of Conservation and Utilization of Characteristic Biological Resources in Western China, College of Life Sciences, Ningxia University, Yinchuan 750021, China.
Donghuan LvKey Laboratory of Conservation and Utilization of Characteristic Biological Resources in Western China, College of Life Sciences, Ningxia University, Yinchuan 750021, China.
Yaxiu XuKey Laboratory of Conservation and Utilization of Characteristic Biological Resources in Western China, College of Life Sciences, Ningxia University, Yinchuan 750021, China.
Xiangyan WangKey Laboratory of Conservation and Utilization of Characteristic Biological Resources in Western China, College of Life Sciences, Ningxia University, Yinchuan 750021, China.
Zhipeng QiKey Laboratory of Conservation and Utilization of Characteristic Biological Resources in Western China, College of Life Sciences, Ningxia University, Yinchuan 750021, China.
Yujie YanKey Laboratory of Conservation and Utilization of Characteristic Biological Resources in Western China, College of Life Sciences, Ningxia University, Yinchuan 750021, China.
Jinghua WangKey Laboratory of Conservation and Utilization of Characteristic Biological Resources in Western China, College of Life Sciences, Ningxia University, Yinchuan 750021, China.
Hongyuan SongKey Laboratory of Conservation and Utilization of Characteristic Biological Resources in Western China, College of Life Sciences, Ningxia University, Yinchuan 750021, China.
Hui YangBureau of Agriculture and Rural of Tongxin County, Wuzhong 751300, China.
Luguo JinBureau of Agriculture and Rural of Tongxin County, Wuzhong 751300, China.
Zhengyi YangBureau of Agriculture and Rural of Tongxin County, Wuzhong 751300, China.
Xiaoning YangBureau of Agriculture and Rural of Tongxin County, Wuzhong 751300, China.
Xiumei KangBureau of Agriculture and Rural of Tongxin County, Wuzhong 751300, China.
Xinfeng LiuKey Laboratory of Conservation and Utilization of Characteristic Biological Resources in Western China, College of Life Sciences, Ningxia University, Yinchuan 750021, China.
Zhuming ZhangCollege of Agriculture, Ningxia University, Yinchuan 750021, China.
Chao WangState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing 100193, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oocyte maturation plays an important role in supporting mammalian reproduction. Histone deacetylase 11 (HDAC11), the only member of the class IV histone deacetylase family and the smallest histone deacetylases (HDACs), has been shown to regulate oocyte maturation in mice and pigs. However, the epigenetic effects of HDACs in follicular granulosa cells in response to LH induction remain elusive in sheep. In this study, the effects of follicular somatic cell-derived HDAC11 on oocyte maturation in Tan sheep are evaluated. The expression changes of HDAC11 and related proteins are detected by means of immunofluorescence, immunohistochemistry, western blot analysis and enzyme-linked immunosorbent assay. Our results indicate that the level of HDAC11 in follicular granulosa cells as well as oocytes in Tan sheep increases with the growth and maturation of the follicles. Specific inhibition of HDAC11 by SIS17 remarkably reduces the oocyte maturation rate under LH supplementation

Indexed as

Granulosa CellsHistone DeacetylasesLuteinizing HormoneOocytesOogenesisAcetylationAnimalsFemaleHistonesIn Vitro Oocyte Maturation TechniquesSheepHistone DeacetylasesHistonesLuteinizing HormoneAREGgranulosa cellH3K9acHDAC11oocyte maturationYAP1

Identifiers

PMID40065721
PMCPMC12616727

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.