ArticleJournal of child psychology and psychiatry, and allied disciplines2025
The influence of deprivation on cortical development and psychotic symptoms in youth.
Article in Journal of child psychology and psychiatry, and allied disciplines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Childhood adversity and psychotic-like experiences in adolescence: Investigating a pathway via disrupted pubertal and grey matter development.JCPP advances · 2026Article
- Individual differences in adolescent cortical development are associated with neighborhood characteristics: Longitudinal findings from the ABCD study.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
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3 authors.
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Abstract
backgroundPeople with early-life experiences of deprivation are more likely to develop psychotic symptoms. While the mechanisms of this relationship are poorly understood, research suggests a role of cortical development.
methodsIn 6323 youth from the Adolescent Brain Cognitive Development study, we examined associations between total, material, interpersonal, cognitive and neighbourhood deprivation at age 9-11 years and psychotic-like experiences (PLEs) 2 years later. We then investigated whether associations were mediated by variation in cortical volume at baseline or rate of change from baseline to follow-up. Sex-specific effects were examined throughout.
resultsAll deprivation measures were associated with greater PLEs. Most of these associations were partially mediated by variation in cortical structure in widespread regions, including lower baseline cortical volume in ventral visual and sensorimotor regions and particularly in females, steeper cortical volume decline in association areas.
conclusionsEarly-life deprivation may be associated with psychotic-like experiences via disruption to cortical structure. This phenomenon is common to several forms of deprivation and continues into early adolescence in certain regions.
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