Evidence map›Paper›PMID 40065568›Full record

ReviewObesity (Silver Spring, Md.)2025

The impact of lifestyle-based weight loss in older adults with obesity on muscle and bone health: a balancing act.

Tiffany M Cortes, Kacey Chae, Colleen M Foy, Denise K Houston, Kristen M Beavers

Abstract readReview
In one paragraph

Review in Obesity (Silver Spring, Md.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
  2. Late-life disability following the action for health in diabetes (Look AHEAD) trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Trial
  3. Article
  4. Article
  5. Authors' reply to 2nd comment on: effect of protein supplementation on hip bone mineral density, cortical thickness, and bone strength in older adult participants during a caloric restriction and aerobic exercise weight loss intervention: a randomized controlled trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  6. Obesity and healthy aging: fat, muscle, and bone trade-offs in an era of potent weight-loss pharmacotherapy.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
    Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tiffany M CortesDivision of Endocrinology and the Sam and Ann Barshop Institute for Longevity and Aging Studies, Department of Medicine, UT Health San Antonio, San Antonio, Texas, USA.
Kacey ChaeDivision of General Internal Medicine, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Colleen M FoyZachary Smith Reynolds Library, Wake Forest University, Winston-Salem, North Carolina, USA.
Denise K HoustonSection on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID https://orcid.org/0000-0002-3355-4304
Kristen M BeaversSection on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID https://orcid.org/0000-0002-7786-4195

Funding

Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI STEPHEN B. KRITCHEVSKY · 2002 to 2026
$36.4M
San Antonio OAIC - Research Education Component (REC)P30AG044271 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Adam Salmon, Elena Volpi · 2015 to 2026
$14.1M
Exercise and Bisphosphonate Use to Minimize Weight Loss Associated Bone Loss among Older AdultsR01AG074979 · NIA · WAKE FOREST UNIVERSITY · PI Daniel P Beavers, Kristen Marie Beavers · 2022 to 2026
$7.1M
Health Services and Outcomes Research for Aging PopulationsT32AG066576 · NIA · JOHNS HOPKINS UNIVERSITY · PI CYNTHIA Melinda BOYD, Jennifer L. Wolff · 2020 to 2026
$3.8M
Incorporating Nutrition, Vests, Education, and Strength Training in Bone Health (INVEST in Bone Health)R01AG059186 · NIA · WAKE FOREST UNIVERSITY · PI BEAVERS, KRISTEN MARIE · 2019 to 2023
$3.0M
Bisphosphonate Use to Mitigate Bone Loss Secondary to Bariatric SurgeryU01AR080969 · NIAMS · WAKE FOREST UNIVERSITY · PI Jamy D Ard, Kristen Marie Beavers · 2022 to 2026
$2.5M
NIAMS NIH HHS U01 AR080969NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG044271NIA NIH HHS P30 AG21332NIA NIH HHS R01 AG059186NIA NIH HHS R01 AG074979NIA NIH HHS T32 AG066576
6 · The paper itself

Abstract

Despite adverse metabolic and functional consequences of obesity (BMI ≥30 kg/m

Indexed as

Bone and BonesLife StyleMuscle, SkeletalObesityWeight LossAgedBone DensityCaloric RestrictionExerciseFemaleHumansMaleResistance Training

Identifiers

PMID40065568
PMCPMC12353011

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.