ArticleMagnetic resonance in medicine2025
High-resolution, volumetric diffusion-weighted MR spectroscopic imaging of the brain.
Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- High-resolution, volumetric diffusion-weighted MR spectroscopic imaging of the brain.Magnetic resonance in medicine · 2025Article
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3 authors.
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Abstract
purposeTo achieve high-resolution, three-dimensional (3D) quantitative diffusion-weighted MR spectroscopic imaging (DW-MRSI) for molecule-specific microstructural imaging of the brain.
methodsWe introduced and integrated several innovative acquisition and processing strategies for DW-MRSI: (a) a new double-spin-echo sequence combining selective excitation, bipolar diffusion encoding, rapid spatiospectral sampling, interleaved water spectroscopic imaging data, and a special sparsely sampled echo-volume-imaging (EVI)-based navigator, (b) a rank-constrained time-resolved reconstruction from the EVI data to capture spatially varying phases, (c) a model-based phase correction for DW-MRSI data, and (d) a multi-b-value subspace-based method for water/lipids removal and spatiospectral reconstruction using learned metabolite subspaces, and e) a hybrid subspace and parametric model-based parameter estimation strategy. Phantom and in vivo experiments were performed to validate the proposed method and demonstrate its ability to map metabolite-specific diffusion parameters in 3D.
resultsThe proposed method generated reproducible metabolite diffusion coefficient estimates, consistent with those from a standard single-voxel DW spectroscopy (SV-DWS) method. High-SNR multi-molecular mean diffusivity (MD) maps can be obtained at a 6.9
conclusionWe demonstrated an unprecedented capability of simultaneous, high-resolution metabolite and diffusion parameter mapping. This imaging capability has strong potential to offer richer molecular and tissue-compartment-specific microstructural information for various clinical and neuroscience applications.
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