Evidence map›Paper›PMID 40065436›Full record

ArticleBMC medical genomics2025

Association of CYP19 gene SNPs (rs7176005 and rs6493497) with polycystic ovary syndrome susceptibility in Northern Chinese women.

Ya-Li Hao, Chun-Miao Liu, Na Wang, Rong-Miao Zhou, Ya-Nan Wei, Xiao-Shuang Bai, Xi Huang

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In one paragraph

Article in BMC medical genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ya-Li Hao *Department of Reproductive Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, Hebei, China.
Chun-Miao Liu *Department of Obstetrics, The Fourth Hospital of Shijiazhuang, Shijiazhuang, 050035, Hebei, China.
Na WangDepartment of Molecular Biology, The Fourth Hospital of Hebei Medical University, NO.12 JianKang Road, Shijiazhuang, 050011, Hebei, China.
Rong-Miao ZhouDepartment of Molecular Biology, The Fourth Hospital of Hebei Medical University, NO.12 JianKang Road, Shijiazhuang, 050011, Hebei, China.
Ya-Nan WeiDepartment of Reproductive Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, Hebei, China.
Xiao-Shuang BaiDepartment of Reproductive Medicine, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, Hebei, China.
Xi HuangDepartment of Molecular Biology, The Fourth Hospital of Hebei Medical University, NO.12 JianKang Road, Shijiazhuang, 050011, Hebei, China. huangxihxl@163.com.

Funding

Medical Science Research Project of Hebei 20241298
6 · The paper itself

Abstract

purposeThe objective of this study was to elucidate the relationship between two single nucleotide polymorphisms (SNPs) rs7176005 and rs6493497 in CYP19 gene and the risk of polycystic ovary syndrome (PCOS) in Northern Chinese women.

methodsIn this case-control study, a total of 340 women with PCOS and 340 matched healthy controls were recruited. Polymerase chain reaction ligase detection reaction (PCR-LDR) method was used to investigate two SNPs (rs7176005 and rs6493497) in the 5'-flanking region of CYP19 gene exon 1.

resultsWe observed a significant association of rs7176005 and rs6493497 with reduced risk of PCOS. Compared with CC genotype, a significant association of CT genotype (p = 0.019), TT genotype (p < 0.001) and combined CT + TT genotype (p < 0.001) with reduced risk of PCOS was observed. The result of linkage disequilibrium analysis showed that these two SNPs are in complete linkage disequilibrium (r

conclusionsThese findings highlight a significant association between CYP19 gene polymorphisms and PCOS susceptibility, implying potential protective effects of T and A alleles. Of course, the major limitation of this study is the sample size of the case-control study. Larger cohort studies are needed to confirm these findings and investigate the underlying causes.

Indexed as

AromataseEast Asian PeopleGenetic Predisposition to DiseasePolycystic Ovary SyndromePolymorphism, Single NucleotideAdultCase-Control StudiesChinaFemaleGene FrequencyGenetic Association StudiesGenotypeHumansLinkage DisequilibriumYoung AdultAromataseCYP19A1 protein, humanCYP19 genePolycystic ovary syndromeRiskSingle nucleotide polymorphismSusceptibility

Identifiers

PMID40065436
PMCPMC11892123

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