ArticleBMC public health2025
The impact of dietary copper intake on cardiovascular morbidity and mortality among hypertensive patients: a longitudinal analysis from NHANES (2001-2018).
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- The Association of Copper Intake with Hearing Loss: a Cross-Sectional Study.Biological trace element research · 2026Article
- Commentary: The Lack of Biomarkers to Assess Copper Status Could be Dangerous to Your Health?Biological trace element research · 2026Article
- Metabolic pathways and cell death modalities in diabetic complications: unraveling pyroptosis, ferroptosis, cuproptosis, and disulfidptosis.Cell death discovery · 2026Review
- Dietary trace mineral intake and risk of all-cause and cardiovascular mortality in population with cardiovascular-kidney-metabolic syndrome stage 0-3: a cohort study.BMC public health · 2026Article
- Copper dyshomeostasis and cardiovascular disease: Molecular mechanisms and new strategies for targeted intervention with cuproptosis (Review).International journal of molecular medicine · 2026Review
- Role of Copper Homeostasis and Cuproptosis in Cardiovascular Disease: Molecular Insights and Metabolic Perspectives.International journal of biological sciences · 2026Review
- Essential and Toxic Elements in Cardiovascular Disease: Pathophysiological Roles and the Emerging Contribution of Hair Mineral Analysis.International journal of molecular sciences · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While the impact of macronutrients on health is well-understood, the influence of micronutrients such as copper on cardiovascular health remains less explored. Copper, vital for heart function and antioxidant defense, may affect cardiovascular health through its role in enzymatic activities that reduce oxidative stress. This study evaluates the relationship between dietary copper intake and cardiovascular outcomes in hypertensive patients using data from the National Health and Nutrition Examination Survey (NHANES) from 2001 to 2018. Findings reveal that higher dietary copper intake is associated with significantly lower cardiovascular disease (CVD) prevalence and mortality rates. A non-linear relationship was identified, indicating an optimal copper intake threshold of approximately 2.85 mg/day. Notably, the protective effects of copper were more pronounced in men, non-diabetic individuals, and those with higher educational levels. These results underscore copper's potential role in preventing cardiovascular complications in hypertensive patients and support the inclusion of copper intake in dietary recommendations to improve cardiovascular health. This study enhances our understanding of how micronutrients influence cardiovascular disease management and aids in developing targeted nutritional interventions.
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