ArticleBMC cancer2025
The mediating role of the TyG index in the relationship between circadian syndrome and cancer among middle-aged and elderly Chinese.
Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Non-traditional metabolic indices predict incident circadian syndrome in middle-aged and older Chinese adults: a nationwide prospective cohort study and machine learning analysis.Lipids in health and disease · 2026Observational
- Association of Circadian Syndrome with Incident Risk of 23 Site-Specific Cancers: A Large-Scale Prospective Study in the UK Biobank.Research (Washington, D.C.) · 2026Article
- The role of instrumental activity of daily living disability in the association between circadian syndrome and cardiometabolic multimorbidity in Chinese middle-aged and older adults.Journal of health, population, and nutrition · 2025Article
- Triglyceride-glucose index as a prognostic indicator in advanced gastric cancer: Insights and future research.World journal of gastroenterology · 2025Article
- Article
- Association between triglyceride-glucose index and its derivatives and lung adenocarcinoma risk: a case-control study in Chinese adults.Frontiers in endocrinology · 2025Article
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Authors and funding
5 authors.
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Abstract
backgroundCircadian Syndrome (CircS) is a significant marker of metabolic imbalance and has been linked to various chronic diseases. However, its relationship with cancer risk remains underexplored. This research aims to explore the relationship between CircS and cancer, while also assessing the possible mediating role of the triglyceride glucose (TyG) index.
methodsBaseline data from the 2011 China Health and Retirement Longitudinal Study (CHARLS) and follow-up data from 2015 were analyzed, including participants' sociodemographic characteristics, health behaviors, and metabolic indicators. Linear regression, mediation analysis, and logistic regression were employed to explore relationships between CircS, cancer risk, and the TyG index, with a dose-response analysis conducted on TyG index and cancer risk.
resultsAmong 7,864 middle-aged and elderly participants, CircS was significantly and positively associated with cancer risk (r = 0.17, P < 0.001). The TyG index showed a significant correlation with both CircS (r = 0.52, P < 0.001) and cancer (r = 0.15, P < 0.001). Mediation modeling indicated that the TyG index partially mediated the association between CircS and cancer, accounting for 23% of this relationship. Additionally, a significant nonlinear dose-response relationship was observed between the TyG index and cancer risk (P
conclusionCircadian syndrome is associated with increased cancer risk, with the TyG index partially mediating this relationship.
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