Evidence map›Paper›PMID 40065283›Full record

ArticleBMC medical genomics2025

A genome-wide association study of methamphetamine use among people with HIV.

A Venkataraman, T Jia, S A Ruderman, C B Haas, R M Nance, L S Mixson, K H Mayer, M S Saag, G Chander, R D Moore and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

A VenkataramanUniversity of Washington, Seattle, WA, USA. avenkata@uw.edu.
T JiaUniversity of Washington, Seattle, WA, USA.
S A RudermanUniversity of Washington, Seattle, WA, USA.
C B HaasUniversity of Washington, Seattle, WA, USA.
R M NanceUniversity of Washington, Seattle, WA, USA.
L S MixsonUniversity of Washington, Seattle, WA, USA.
K H MayerHarvard University, Cambridge, MA, USA.
M S SaagUniversity of Alabama, Birmingham, AL, USA.
G ChanderUniversity of Washington, Seattle, WA, USA.
R D MooreJohns Hopkins University, Baltimore, MD, USA.
J JacobsonCase Western Reserve University, Cleveland, OH, USA.
S NapravnikUniversity of North Carolina, Chapel Hill, NC, USA.
K ChristopolousUniversity of California, San Francisco, CA, USA.
W J LeeIcahn School of Medicine at Mount Sinai, New York, NY, USA.
B M WhitneyUniversity of Washington, Seattle, WA, USA.
I PeterIcahn School of Medicine at Mount Sinai, New York, NY, USA.
H M CraneUniversity of Washington, Seattle, WA, USA.
J A C DelaneyUniversity of Washington, Seattle, WA, USA.
S LindströmUniversity of Washington, Seattle, WA, USA. saralind@uw.edu.

Funding

Unsolicited R24 for the CFAR-Network of Integrated Clinical Sciences, CNICSR24AI067039 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael S. Saag · 2006 to 2026
$99.4M
Substance use patterns and contexts: impact on epigenetic age and prevention strategies in an HIV clinical care cohortR01DA047045 · NIDA · UNIVERSITY OF WASHINGTON · PI Heidi M. Crane, Joseph Austin Delaney · 2018 to 2026
$5.1M
Pharmacogenomics and Systems Pharmacology Approaches to Toxicity, Tolerability, and Comorbidities Associated with Modern Antiretroviral TherapiesR01HG010649 · NHGRI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CRANE, HEIDI M., PETER, INGA · 2019 to 2023
$4.5M
NHGRI NIH HHS R01 HG010649NIAAA NIH HHS R24AI067039NIAID NIH HHS R24 AI067039NIDA NIH HHS R01 DA047045NIH HHS R01HG010649
6 · The paper itself

Abstract

backgroundAmphetamine-like stimulants are the most used psychostimulants in the world; methamphetamine use is the most prevalent in people with HIV. Prolonged methamphetamine use can cause lasting damage to the heart, gut, and brain, as well as auditory hallucinations and paranoid thinking. However, relatively little is known about methamphetamine use and its genetic contributors.

methodsUsing genetic information from the Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) cohort, we conducted a multi-ancestry genome-wide association study (GWAS) of methamphetamine use among people with HIV (n = 1,196 reported ever use, n = 4,750 reported never use).

resultsNo single nucleotide polymorphism was statistically associated with methamphetamine use at the genome-wide level (p < 5 * 10 DISCUSSION: Our study suggests that there is no single strong genetic contributor to lifetime use of methamphetamine in people with HIV enrolled in CNICS. Larger studies with more refined outcome assessment are warranted to further understand the contribution of genetics to methamphetamine use and use disorder. Investigation into social and environmental contributors to methamphetamine use are similarly necessary.

Indexed as

Amphetamine-Related DisordersGenome-Wide Association StudyHIV InfectionsMethamphetamineAdultFemaleHumansMaleMiddle AgedPolymorphism, Single NucleotideMethamphetamineGenetic epidemiologyGWASHIVMethamphetamineStimulant useSubstance use

Identifiers

PMID40065283
PMCPMC11895338

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.