ArticleBMC public health2025
Association between uric acid/high-density lipoprotein cholesterol ratio and testosterone deficiency in adult American men: findings from the national health and nutrition examination survey 2011-2016.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Enhanced prediction of coronary heart disease risk in diabetic patients via Machine learning incorporating multiple inflammatory and metabolic indices: A study with Dual-Cohort validation.International journal of cardiology. Heart & vasculature · 2026Article
- Association between TyHGB and hyperuricemia and gout in patients with type-2 diabetes mellitus.BMC endocrine disorders · 2026Article
- Association Between Systemic Immune-Inflammation Index and Thyroid Function: A Cross-Sectional Population-Based Study.International journal of endocrinology · 2026Article
- Serum uric acid-to-HDL cholesterol ratio and stroke prevalence: NHANES 1999-2018 with external support from an imaging-confirmed hemorrhagic stroke dataset.Frontiers in neurologyArticle
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7 authors.
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Abstract
backgroundTestosterone deficiency (TD) is a globally recognized health concern, closely linked to disruptions in uric acid and lipid metabolism. Recently, the uric acid to high-density lipoprotein cholesterol ratio (UHR) has emerged as a comprehensive index for assessing the impact of inflammation and metabolic disturbances on disease risk. Therefore, we intended to explore the association of UHR with total testosterone levels and the risk of TD among US male adults.
methodsThe analysis was based on data from the National Health and Nutrition Examination Survey (NHANES) conducted between January 2011 and December 2016. All eligible participants were males aged 20 and older who had complete data for UHR and testosterone levels. The associations between UHR and total testosterone levels and the risk of TD were examined using weighted multivariable linear and logistic regression analysis, respectively. To visually demonstrate the linear relationship between them, weighted regression using generalized additive models and smooth curve fits were applied. Furthermore, subgroup analyses with interaction tests were executed to evaluate the stability of the outcomes.
resultsFinally, a total of 2,844 men were enrolled in the study with the weighted mean age of 47.72 ± 0.42 years. Of these, 592 were diagnosed with TD. After controlling for potential confounders, the continuous UHR exhibited a positive linear correlation with the risk of TD (OR = 1.08, 95%CI: 1.04-1.11, P < 0.001) and a negative linear correlation with total testosterone levels (β=-7.82, 95%CI: -10.47 to -5.17, P < 0.0001). When UHR was categorized into quartiles, with Q1 as the reference, participants in Q4 had significantly lower total testosterone levels (β = -96.64, 95% CI: -129.39 to -63.90, P < 0.0001) and a higher risk of TD (OR = 2.35, 95%CI: 1.45-3.80, P = 0.001). These associations remained stable in subgroup analyses without significant interaction (all P for interaction > 0.05).
conclusionsThe study indicates that, among adult males, higher UHR is negatively correlated with total testosterone levels and positively associated with the risk of TD. This suggests its potential value for early disease diagnosis and intervention. However, further clinical studies are needed to validate these findings.
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