ArticleBMC infectious diseases2025
The relationship between hemoglobin, albumin, lymphocyte, and platelet (HALP) score and 28-day mortality in patients with sepsis: a retrospective analysis of the MIMIC-IV database.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Clinical and laboratory predictors of mortality in Fournier's gangrene: prognostic role of the HALP score.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026Article
- Association of the Modified HALP Score with Disease Complexity in Deep Neck Infections: A Dual-Center Retrospective Study.Diagnostics (Basel, Switzerland) · 2026Article
- Comparative Analysis of Novel Inflammatory and Nutritional Indices (m-HALP, HALP, SII, SIRI) for Risk Stratification in Septic Patients: A Retrospective Cohort Study.Life (Basel, Switzerland) · 2026Article
- Application of a machine learning model integrating T cell subsets and clinical markers in 28-Day mortality prediction of sepsis patients.Clinical and experimental medicine · 2026Article
- Predictive role of prognostic nutritional index and geriatric nutritional risk index for postoperative mortality risk in patients with aortic dissection: a systematic review and meta-analysis.Journal of thoracic disease · 2026Article
- Prognostic Value of the Preoperative HALP Score for Survival in Non-Malignant Liver Transplant Recipients.Journal of clinical medicine · 2026Article
- Development and validation of an interpretable machine learning model for predicting sepsis risk in pleural effusion patients.Journal of thoracic disease · 2026Article
- Comparative Prognostic Performance of HALP, PIV, and Naples Prognostic Score in Critically Ill Patients with Sepsis: A Retrospective Multicentre Cohort Study.Journal of clinical medicine · 2026Article
- Predictive value of the hemoglobin-albumin-lymphocyte-platelet score for intravenous immunoglobulin resistance in children with Kawasaki disease.Italian journal of pediatrics · 2026Article
- Nonlinear correlation between lactate levels and 28-day all-cause mortality in patients with sepsis complicated by acute respiratory distress syndrome (ARDS): a retrospective study based on the MIMIC-IV database.BMC medical informatics and decision making · 2026Article
- Association between HALP score and in-hospital outcomes in patients with acute kidney injury: a retrospective cohort study.Scientific reports · 2026Article
- Article
- Efficacy analysis of early incision and drainage on necrotizing fasciitis, a retrospective study.BMC infectious diseases · 2026Article
- Hematological Inflammatory Indices and the HALP Score for Pathogen Differentiation in Culture-Proven Late-Onset Neonatal Sepsis.Children (Basel, Switzerland) · 2026Article
- Baseline bicarbonate level is associated with apnea of prematurity in preterm neonates with neonatal jaundice: insights from the Medical Information Mart for Intensive Care III (MIMIC-III) database.Translational pediatrics · 2026Article
- Comparison of FGSI and HALP scores for mortality prediction in Fournier's Gangrene: A retrospective analysis.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Inflammatory indices as independent predictors of in-hospital mortality in acute upper gastrointestinal bleeding.BMC gastroenterology · 2026Observational
- Hemoglobin-albumin-lymphocyte-platelet score associated with diabetic foot severity, unlike modified systemic immune-inflammatory index and modified systemic inflammatory response index.Frontiers in endocrinology · 2026Article
- HALP score and 30-day mortality: an observational analysis of clinical associations in Pneumonia.PeerJ · 2026Observational
- The impact of early nutritional and immune status assessment on all-cause mortality in patients with intracerebral hemorrhage in the intensive care unit: a retrospective study.Frontiers in medicine · 2026Article
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Abstract
backgroundIn recent years, the hemoglobin, albumin, lymphocyte, and platelet (HALP) score has emerged as a potential marker of immunological and nutritional status. This study aimed to evaluate the association between the HALP score and prognosis in patients with sepsis.
methodsThis retrospective cohort study analyzed sepsis patients using clinical data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Patients were classified into Low-score and High-score groups. Confounding factors were controlled through propensity score matching (PSM) analysis. The primary outcome was 28-day mortality in individuals with sepsis. Survival probabilities between groups were compared using Kaplan-Meier curves. Multivariable Cox regression analysis and a smoothing spline fitting curve were employed to investigate the relationship between the HALP score and 28-day mortality. ROC curve analysis and subgroup analysis were performed to evaluate the predictive ability of the HALP score and its components.
resultsA total of 2,968 sepsis patients were included, with 809 (27.26%) deaths within 28 days. After PSM analysis, the High-score group had a 24% lower risk of 28-day mortality compared to the Low-score group (HR, 0.76; 95% CI, 0.64-0.91). In the unmatched cohort, the multivariable Cox regression model also indicated that the High-score group had a lower 28-day mortality risk (HR, 0.78; 95% CI, 0.67-0.91). The smoothing spline fitting curve showed a nonlinear relationship between the HALP score and 28-day mortality, with an inflection point at 24.69. When the HALP score was below 24.69, an increase of one point in the HALP score was associated with a 2% reduction in 28-day mortality (HR, 0.98; 95% CI, 0.97-0.99). The HALP score provided incremental predictive value for 28-day mortality when combined with the SOFA score. Albumin was identified as the most influential component of the HALP score.
conclusionAmong patients with sepsis, the HALP score exhibited a nonlinear relationship with 28-day mortality. An elevated HALP score is associated with reduced 28-day, 90-day, 360-day, and in-hospital mortality among sepsis patients.
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