ArticleNature neuroscience2025
Constructing future behavior in the hippocampal formation through composition and replay.
Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Retrospective Grid Cells in the Medial Entorhinal Cortex Encode Past Paths During Spatial Navigation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The compositionality continuum as a principle for studying the neural basis of intelligence.Nature neuroscience · 2026Review
- Principal Components Analysis Relates Hippocampal Trisynaptic Circuit to Vividness of Visual Mental Imagery.Brain and behavior · 2026Article
- Cognitive maps as a medium for thought.Trends in cognitive sciences · 2026Review
- Shared neural geometries for bilingual semantic representations in human hippocampal neurons.Cell · 2026Article
- Natural auditory behaviors invoke cognitive brain networks.Current opinion in neurobiology · 2026Review
- Human hippocampal ripples coordinate planning sequences and compositional representations in neocortex.Nature neuroscience · 2026Article
- Dopamine in the ventral and tail of striatum supports global and local evaluation in reward-threat conflict.bioRxiv : the preprint server for biology · 2026Article
- Action information is integrated into entorhinal representations of conceptual space and is reflected in eye movements.PLoS biology · 2026Article
- Persistent representation of a prior schema in the orbitofrontal cortex facilitates learning of a conflicting schema.Nature communications · 2026Article
- Continuous attractor dynamics in spatial navigation: from population geometry to flexible computation.Frontiers in neuroscience · 2026Review
- Neural sampling from cognitive maps enables goal-directed imagination and planning.Nature machine intelligence · 2026Article
- Composing egocentric and allocentric maps for flexible navigation.PLoS computational biology · 2026Article
- A predictive map learned from diverse entorhinal inputs explains the role of context-dependent reorganization of hippocampal place cells.Frontiers in computational neuroscience · 2026Article
- Between planning and map building: Prioritizing replay when future goals are uncertain.Neuron · 2025Review
- Deep neural networks and stochastic methods for cognitive modeling of rat behavioral dynamics inCognitive neurodynamics · 2025Article
- Reasoning with programs in replay.bioRxiv : the preprint server for biology · 2025Article
- Prioritizing replay when future goals are unknown.bioRxiv : the preprint server for biology · 2025Article
- The brain creates action-based maps of the world near the body.Nature neuroscience · 2025Article
- Constructing future behavior in the hippocampal formation through composition and replay.Nature neuroscience · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The hippocampus is critical for memory, imagination and constructive reasoning. Recent models have suggested that its neuronal responses can be well explained by state spaces that model the transitions between experiences. Here we use simulations and hippocampal recordings to reconcile these views. We show that if state spaces are constructed compositionally from existing building blocks, or primitives, hippocampal responses can be interpreted as compositional memories, binding these primitives together. Critically, this enables agents to behave optimally in new environments with no new learning, inferring behavior directly from the composition. We predict a role for hippocampal replay in building and consolidating these compositional memories. We test these predictions in two datasets by showing that replay events from newly discovered landmarks induce and strengthen new remote firing fields. When the landmark is moved, replay builds a new firing field at the same vector to the new location. Together, these findings provide a framework for reasoning about compositional memories and demonstrate that such memories are formed in hippocampal replay.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.