ArticleScientific reports2025
Osteoarthritis burden and inequality from 1990 to 2021: a systematic analysis for the global burden of disease Study 2021.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Exosome therapy for knee osteoarthritis: a network meta-analysis based on rat models.Stem cells translational medicine · 2026Article
- The Microbiota Metabolite-Joint Axis: Mechanistic Insights and Therapeutic Targets for Osteoarthritis.Biomedicines · 2026Review
- Smart Nanodelivery Systems for Immunometabolic Modulation in Osteoarthritis.Exploration (Beijing, China) · 2026Review
- Advances in the application of human amniotic membrane for tissue repair.Cell regeneration (London, England) · 2026Review
- Ferroptosis-Driven Senescence Loop as a Central Amplifier of Osteoarthritis Progression.Biomolecules & therapeutics · 2026Review
- Perioperative denosumab exposure and risk of revision after total hip and knee arthroplasty in osteoarthritis: a registry-based data linkage study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Article
- Frailty Transition and Risk of New-Onset Arthritis Among Adults Aged 45 Years and Older: A Longitudinal Analysis of CHARLS.Healthcare (Basel, Switzerland) · 2026Article
- Computational Insights into Flavonoids for ADAMTS-5 Exosite Inhibition in Knee Osteoarthritis: Docking, MD Simulations, and Machine Learning-Guided Structure Prediction.Molecules (Basel, Switzerland) · 2026Article
- Safety and clinical performance of intra-articular high-purity sodium hyaluronate injection in patients with knee osteoarthritis: a 28-week post-market clinical follow-up study.Clinical rheumatology · 2026Article
- Ulvan and Ulva oligosaccharides from Ulva sp. attenuate osteoarthritis in a high-fat diet and ligamentous meniscal injury-induced rat model.Bioresources and bioprocessing · 2026Article
- Neuromuscular and Kinematic Strategies During Step-Up and Down-Forwards Task in Individuals with Knee Osteoarthritis.Journal of clinical medicine · 2026Article
- Nutritional Interventions in Osteoarthritis: Mechanisms, Clinical Evidence, and Translational Opportunities.Nutrients · 2026Review
- Epidemiological trends and burden of osteoarthritis in the United States: insights from the GBD 2021 study.Archives of medical science : AMS · 2026Article
- Warm Needle Acupuncture Attenuates Pain-Related Responses and Inflammation in Knee Osteoarthritis: Evidence for Involvement of TAK1/MAPK Signaling from Human Cartilage and Experimental Models.Journal of pain research · 2026Article
- Clinical efficacy of intra-articular sodium hyaluronate injection and optimizing the puncture site in knee osteoarthritis.American journal of translational research · 2026Article
- Global Burden of Hip and Knee Osteoarthritis Attributable to Metabolic Risks in Women of Reproductive Age, 1990-2021: A Systematic Analysis from the Global Burden of Disease Study 2021.International journal of women's health · 2026Article
- Metabolic pathways linking air pollution to osteoarthritis: Insights from a prospective cohort.PloS one · 2026Article
- Temporal trends and future projections of hand osteoarthritis burden in China from 1990 to 2021.Therapeutic advances in musculoskeletal disease · 2026Article
- Leucine Attenuates Osteoarthritis via mTORC1/LXRα-Mediated Macrophage Reprogramming and Rspo2/β-Catenin Axis Suppression.Cartilage · 2025Article
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4 authors.
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Abstract
Osteoarthritis (OA) is a major global health burden, affecting millions and causing significant disability. Understanding its trends and determinants is crucial for effective management and prevention. We analyzed data from the Global Burden of Diseases (GBD) study 2021 to assess OA incidence, Years Lived with Disability (YLDs), and age-standardized rates (ASIR/ASYR) from 1990 to 2021. We explored trends and determinants across gender, region, and Socio-Demographic Index (SDI) quintiles using Joinpoint regression, Age-Period-Cohort (APC) modeling, decomposition, and inequality analyses. The global incidence of OA surged from 20.9 million in 1990 to 46.6 million cases in 2021, with an AAPC of 0.29%. Correspondingly, YLDs escalated from 8.92 million to 21.30 million, reflecting an AAPC of 0.30%. Disparities exist across SDI quintiles, with higher rates observed in high SDI countries. Women consistently experience a higher burden compared to men. Asian regions demonstrate the fastest rise in ASYR. High BMI contributes significantly to OA burden, particularly in high SDI countries. The rising burden of OA necessitates urgent attention. Interventions targeting modifiable risk factors, such as obesity, and early detection and management strategies are crucial. Addressing gender disparities and health inequalities, particularly in high SDI countries, is essential for effective OA prevention and control.
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