Evidence map›Paper›PMID 40065117›Full record

ArticleNPJ digital medicine2025

Smartphone conjunctiva photography for malaria risk stratification in asymptomatic school age children.

Shaun G Hong, Sang Mok Park, Semin Kwon, Haripriya Sakthivel, Sreeram P Nagappa, Jung Woo Leem, Steven R Steinhubl, Pascal Ngiruwonsanga, Jean-Louis N Mangara, Célestin Twizere and 1 more

Abstract read
In one paragraph

Article in NPJ digital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shaun G HongWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Sang Mok ParkWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Semin KwonWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Haripriya SakthivelWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Sreeram P NagappaWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Jung Woo LeemWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Steven R SteinhublWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Pascal NgiruwonsangaGakoma District Hospital, Gisagara District, Southern Province, Rwanda.
Jean-Louis N MangaraMalaria, Neglected Tropical Diseases and Other Parasitic Diseases Division, Rwanda Biomedical Center, Kigali, Rwanda.
Célestin TwizereCenter of Excellence in Biomedical Engineering and eHealth, University of Rwanda, Kigali, Rwanda.
Young L KimWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA. youngkim@purdue.edu.

Funding

Maternal mHealth blood hemoglobin analysis with informed deep learningR01EB033788 · NIBIB · PURDUE UNIVERSITY · PI Young L Kim, Martin Chieng Were · 2023 to 2026
$2.0M
Risk stratification of malaria among school-age children with mHealth spectroscopy of blood analysisR33TW012486 · FIC · PURDUE UNIVERSITY · PI Young L Kim · 2024 to 2026
$771k
Risk stratification of malaria among school-age children with mHealth spectroscopy of blood analysisR21TW012486 · FIC · PURDUE UNIVERSITY · PI KIM, YOUNG L · 2022 to 2023
$339k
FIC NIH HHS R21 TW012486FIC NIH HHS R33 TW012486NIBIB NIH HHS R01 EB033788NIH HHS R33TW012486
6 · The paper itself

Abstract

Malaria remains a major global health challenge. Although effective control relies on testing all suspected cases, asymptomatic infections in school-age children are frequently overlooked. Advances in retinal imaging and computer vision have enhanced malaria detection. However, noninvasive, point-of-care malaria detection remains unrealized, partly because of the need for specialized equipment. Here we report radiomic analyses of 4302 photographs of the palpebral conjunctiva captured using unmodified smartphone cameras from asymptomatic 405 participants aged 5 to 15 years to predict malaria risk. Our neural network classification model of radiomic features achieves an area under the receiver operating characteristic curve of 0.76 with 95% confidence intervals from 0.68 to 0.84 in distinguishing between malaria-infected and non-infected cases in endemic regions. Photographing the inner eyelid provides the advantages of easy accessibility and direct exposure to the microvasculature. This mobile health approach has the potential for malaria prescreening and managing febrile illness in resource-limited settings.

Identifiers

PMID40065117
PMCPMC11893748

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.