ArticleScientific reports2025
Density and structure of DNA immobilised on gold nanoparticles affect sensitivity in nucleic acid detection.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- DNA-hybridization on gold nanospheres: a dual-fluorescence investigation of surface loading and strand length effects.Journal of biomedical optics · 2026Article
- Nanomaterial-nucleic acid probe synergy: accelerating rapid pathogen detection and antimicrobial susceptibility testing in bloodstream infections.Folia microbiologica · 2026Review
- Nucleic acid detection based on single-cluster analysis of cross-linking aggregates of DNA-modified gold nanoparticles using a dark-field microscope.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026Article
- Eco-friendly synthesis of gold nanoparticles using Gracilaria gracilis with antioxidant potential and biocompatibility.Scientific reports · 2026Article
- Gold Nanoparticle-Enhanced Recombinase Polymerase Amplification for Rapid Visual Detection ofBiosensors · 2025Article
- Construction of the indicator-free electrochemical biosensor with magnetically self-assembly based on FeFrontiers in chemistry · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Gold nanoparticles (AuNPs) are used as colorimetric biosensors that, combined with immobilised single-stranded DNA (ssDNA-AuNPs), can be used in genetic diagnosis because of their rapid and sequence-specific aggregation properties. Herein, we investigated the effect of the steric structure and density of immobilised DNA on AuNPs in non-crosslinking aggregation-based nucleic acid detection. Detection sensitivity improved with decreasing DNA density for linear conformations, but worsened for those with more rigid stem structures. We controlled the density of immobilised DNA using two different methods and investigated the aggregation behaviour of ssDNA-AuNPs. Interestingly, controlling the immobilised DNA density through ethylene glycol treatment had different effects on ssDNA-AuNP aggregation compared to those of alkanethiol substitution. This study suggests that the sensitivity of ssDNA-AuNPs for detecting target DNA could be affected by density and structure of the immobilised DNA.
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Registered trials
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