Evidence map›Paper›PMID 40065016›Full record

ArticleScientific reports2025

A prospective cohort study on the trajectory of health-related quality of life in adult childhood cancer survivors attending a follow-up care program.

Charlotte E Kull, Lisa Vifian, Jörg D Leuppi, Christine Baumgartner, Maria Bösing, Katharina Roser, Gisela Michel, Jochen Rössler, Eva Maria Tinner, Maria M Wertli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Charlotte E Kull *Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. charlotte.kull@swissonline.ch.
Lisa Vifian *Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Jörg D LeuppiUniversity Institute of Internal Medicine, Kantonsspital Baselland, Liestal, Switzerland.
Christine BaumgartnerDepartment of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Maria BösingUniversity Institute of Internal Medicine, Kantonsspital Baselland, Liestal, Switzerland.
Katharina RoserFaculty of Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland.
Gisela MichelFaculty of Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland.
Jochen RösslerDivision of Pediatric Hematooncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Eva Maria Tinner *Division of Pediatric Hematooncology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Maria M Wertli *Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Funding

Basel Region Childhood Cancer Foundation #2020-F009Berner Stiftung für krebskranke Kinder und Jugendliche N/AScience funds of the University Institute of Internal Medicine of the cantonal hospital Baselland N/A
6 · The paper itself

Abstract

Follow-up care in adult childhood cancer survivors (ACCS) aims to screen for, prevent, and treat potential late effects. The trajectory of ACCS' health-related quality of life (HRQoL) attending follow-up care is unclear. We investigated changes in HRQoL of ACCS attending a follow-up care program. The primary outcome was the minimal clinically important decrease (MCID) in HRQoL of ≥ 5 points in the mental (MCS) and/or physical component score (PCS) of the 36-item Short Form (SF-36) between baseline and follow-up (3-months after the first visit). We compared baseline characteristics, psychological factors, satisfaction, and distress (measured using the Brief Symptom Inventory). In 47 ACCS (100%), no significant change in the overall median MCS and PCS was observed. In 14 ACCS (29.8%) a MCID in HRQoL was observed. Compared to ACCS without a MCID, they reported lower PCS (median 45.2 [31.7; 51.4] vs. 55.6 [46.1; 57.6], p = 0.007), a higher proportion of low physical health (PCS < 48; 71.4% vs. 27.3%, p = 0.009) and distress (50% vs. 18.8%, p = 0.030) at baseline. Satisfaction was high (94.9%). One in three ACCS experienced a clinically important decrease in HRQoL after follow-up care, with higher rates in those with lower physical health and higher psychological distress at baseline.

Indexed as

Cancer SurvivorsNeoplasmsQuality of LifeAdolescentAdultAftercareChildFemaleFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesSurveys and QuestionnairesYoung AdultCancer survivorChildhood cancerDistressHealth related quality of lifeLate effectsQuality of life

Identifiers

PMID40065016
PMCPMC11894196

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.