Evidence map›Paper›PMID 40064972›Full record

ArticleNature communications2025

Bicomponent nano- and microfiber aerogels for effective management of junctional hemorrhage.

S M Shatil Shahriar, Syed Muntazir Andrabi, Al-Murtadha Al-Gahmi, Zishuo Yan, Alec D McCarthy, Chenlong Wang, Zakariya A Yusuf, Navatha Shree Sharma, Milton E Busquets, Mallory I Nilles and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

S M Shatil Shahriar *Department of Surgery - Transplant and Mary & Dick Holland Regenerative Medicine Program, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Syed Muntazir Andrabi *Department of Surgery - Transplant and Mary & Dick Holland Regenerative Medicine Program, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.ORCID http://orcid.org/0000-0002-2998-2971
Al-Murtadha Al-Gahmi *Department of Surgery - General Surgery, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Zishuo YanDepartment of Surgery - Transplant and Mary & Dick Holland Regenerative Medicine Program, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Alec D McCarthyDepartment of Surgery - Transplant and Mary & Dick Holland Regenerative Medicine Program, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Chenlong WangDepartment of Surgery - Transplant and Mary & Dick Holland Regenerative Medicine Program, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Zakariya A YusufDepartment of Surgery - Transplant and Mary & Dick Holland Regenerative Medicine Program, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Navatha Shree SharmaDepartment of Surgery - Transplant and Mary & Dick Holland Regenerative Medicine Program, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Milton E BusquetsDepartment of Surgery - Transplant and Mary & Dick Holland Regenerative Medicine Program, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Mallory I NillesDepartment of Surgery - Transplant and Mary & Dick Holland Regenerative Medicine Program, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Carlos Poblete JaraDepartment of Surgery - Vascular Surgery, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Kai YangDepartment of Surgery - Plastic & Reconstructive Surgery, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Mark A CarlsonDepartment of Surgery - General Surgery, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA. macarlso@unmc.edu.ORCID http://orcid.org/0000-0002-8113-9199
Jingwei XieDepartment of Surgery - Transplant and Mary & Dick Holland Regenerative Medicine Program, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA. jingwei.xie@unmc.edu.ORCID http://orcid.org/0000-0002-8126-1397

Funding

Novel Janus-type Antimicrobial Dressings for the Treatment of Biofilms in Chronic WoundsR01GM138552 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WANG, GUANGSHUN, XIE, JINGWEI · 2020 to 2023
$2.2M
NIGMS NIH HHS R01 GM138552United States Department of Defense | United States Army | Army Medical Command | Congressionally Directed Medical Research Programs (CDMRP) W81XWH2010208U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R01GM138552
6 · The paper itself

Abstract

Managing junctional hemorrhage is challenging due to ineffective existing techniques, with the groin being the most common site, accounting for approximately 19.2% of potentially survivable field deaths. Here, we report a bicomponent nano- and microfiber aerogel (NMA) for injection into deep, narrow junctional wounds to effectively halt bleeding. The aerogel comprises intertwined poly(lactic acid) nanofibers and poly(ε-caprolactone) microfibers, with mechanical properties tunable through crosslinking. Optimized aerogels demonstrate improved resilience, toughness, and elasticity, enabling rapid re-expansion upon blood contact. They demonstrate superior blood absorption and clotting efficacy compared to commercial products (i.e., QuikClot® Combat Gauze and XStat®). Most importantly, in a lethal swine junctional wound model (Yorkshire swine, both male and female, n = 5), aerogel treatment achieved immediate hemostasis, a 100% survival rate, no rebleeding, hemodynamic stability, and stable coagulation, hematologic, and arterial blood gas testing.

Indexed as

HemorrhageNanofibersAnimalsDisease Models, AnimalFemaleGelsMalePolyestersSwineGelsPolyesterspoly(lactide)

Identifiers

PMID40064972
PMCPMC11893793

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.