ArticleScientific reports2025
Exploring the influence of polysaccharide on gastrointestinal stability, drug release and formation mechanism of nanoparticles in Zhimu and Huangbai herb pair decoction.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Engineering Oral Nanoparticles: Navigating Biological Barriers in the Gastrointestinal Tract.Pharmaceutical research · 2026Review
- Review
- Supramolecular self-assembly in Traditional Chinese Medicine: molecular mechanisms, material basis of decoction efficacy, compatibility interpretation, and biomedical applications.Chinese medicine · 2026Review
- Zhimu-Huangbai codecoction for the treatment of type II diabetes mellitus through its self-assembling nanoparticles.Chinese medicine · 2026Article
- Polysaccharides from Er Chen Decoction: gastrointestinal fate, gut microbiota modulation and metabolomics.Frontiers in microbiology · 2026Article
- Curcumin for inflammatory bowel disease therapy: advances in mechanisms, clinical applications, and drug delivery.Archives of pharmacal research · 2025Review
- Self-Assembled Safflower Polysaccharide Nanoparticles as a Targeted Drug Delivery System for Enhanced Therapy of Hepatocellular Carcinoma.International journal of nanomedicine · 2025Article
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Abstract
Natural polysaccharides with multiple biological activities from traditional Chinese medicine (TCM) can be self-assembled. Natural nanoparticles have been found to exist in TCM decoctions. However, the influence of polysaccharides in TCM decoctions on the formation mechanism, drug release and gastrointestinal stability of nanoparticles remains unclear. Therefore, using Zhimu and Huangbai herb pair decoction (ZBD) as an example, this study aimed to reveal the effects of polysaccharides on the formation, gastrointestinal stability and in vitro release of nanoparticles (N-ZBD) in ZBD. First, N-ZBD was successfully isolated by high-speed centrifugation with an average particle size of 225.9 nm, PDI of 0.53 and zeta potential of -13.00 mV, and N-ZBD is mainly composed of small active compounds and polysaccharides. Interestingly, gastrointestinal stability results showed that N-ZBD had good stability while and the nanoparticles after polysaccharide removal (RPN-ZBD) were degraded within 4 h, indicating that polysaccharide can protect the stability of nanoparticles in the gastrointestinal environment. Moreover, in vitro drug release results showed that compared with free drugs and RPN-ZBD, N-ZBD has obvious slow-release behavior in simulated gastric fluid and simulated intestinal fluid, suggesting that polysaccharides contribute to the slow release of N-ZBD. The critical micelle concentration (CMC) of polysaccharides was 0.63 mg/mL, which could self-assemble with small active compounds to form N-ZBD. In conclusion, polysaccharides of ZBD were essential for N-ZBD formation, and could protect the stability of N-ZBD in the gastrointestinal environment and contribute to its slow drug release.
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