Evidence map›Paper›PMID 40064887›Full record

ArticleNature communications2025

TET2 deficiency increases the competitive advantage of hematopoietic stem and progenitor cells through upregulation of thrombopoietin receptor signaling.

Yitong Yang, Severine Cathelin, Alex C H Liu, Amit Subedi, Abdula Maher, Mohsen Hosseini, Dhanoop Manikoth Ayyathan, Robert Vanner, Steven M Chan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yitong YangDepartment of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto, Toronto, M5G 1L7, Canada.
Severine CathelinPrincess Margaret Cancer Centre, University Health Network, Toronto, M5G 1L7, Canada.
Alex C H LiuDepartment of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto, Toronto, M5G 1L7, Canada.
Amit SubediPrincess Margaret Cancer Centre, University Health Network, Toronto, M5G 1L7, Canada.
Abdula MaherPrincess Margaret Cancer Centre, University Health Network, Toronto, M5G 1L7, Canada.ORCID http://orcid.org/0009-0009-6535-6888
Mohsen HosseiniPrincess Margaret Cancer Centre, University Health Network, Toronto, M5G 1L7, Canada.
Dhanoop Manikoth AyyathanPrincess Margaret Cancer Centre, University Health Network, Toronto, M5G 1L7, Canada.
Robert VannerPrincess Margaret Cancer Centre, University Health Network, Toronto, M5G 1L7, Canada.ORCID http://orcid.org/0000-0003-1169-1778
Steven M ChanDepartment of Medical Biophysics, Temerty Faculty of Medicine, University of Toronto, Toronto, M5G 1L7, Canada. steven.chan@uhn.ca.ORCID http://orcid.org/0000-0002-4354-0731

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ten-Eleven Translocation-2 (TET2) mutations drive the expansion of mutant hematopoietic stem cells (HSCs) in clonal hematopoiesis (CH). However, the precise mechanisms by which TET2 mutations confer a competitive advantage to HSCs remain unclear. Here, through an epigenetic drug screen, we discover that inhibition of disruptor of telomeric silencing 1-like (DOT1L), a H3K79 methyltransferase, selectively reduces the fitness of Tet2 knockout (Tet2

Indexed as

DNA-Binding ProteinsHematopoietic Stem CellsProto-Oncogene ProteinsReceptors, ThrombopoietinAnimalsClonal HematopoiesisDioxygenasesHistone-Lysine N-MethyltransferaseHistonesHumansMiceMice, Inbred C57BLMice, KnockoutMutationSignal TransductionUp-RegulationDioxygenasesDNA-Binding ProteinsHistone-Lysine N-MethyltransferaseHistonesMpl protein, mouseProto-Oncogene ProteinsReceptors, ThrombopoietinTET2 protein, humanTet2 protein, mouse

Identifiers

PMID40064887
PMCPMC11894142

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.