Evidence map›Paper›PMID 40064868›Full record

Trial reportNature communications2025

Edaravone dexborneol for ischemic stroke with sufficient recanalization after thrombectomy: a randomized phase II trial.

Hui-Sheng Chen, Zi-Ai Zhao, Xin-Yu Shen, Si-Qi Qiu, Yu Cui, Jing Qiu, Wei Li, Hong Zhang, Wen-Huo Chen, Li-Hua Wang and 8 more

Abstract readClinical Trial, Phase IIRandomized Controlled TrialMulticenter Study
In one paragraph

Trial report in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. A Multi-Omics Integration Analysis Reveals ThatAntioxidants (Basel, Switzerland) · 2026
    Article
  13. Cytoprotection Concepts for Ischemic Stroke in the Recanalization Era.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Hui-Sheng ChenDepartment of Neurology, General Hospital of Northern Theater Command, Shenyang, China. chszh@aliyun.com.ORCID http://orcid.org/0000-0002-7486-1992
Zi-Ai ZhaoDepartment of Neurology, General Hospital of Northern Theater Command, Shenyang, China.
Xin-Yu ShenDepartment of Neurology, General Hospital of Northern Theater Command, Shenyang, China.
Si-Qi QiuDepartment of Neurology, General Hospital of Northern Theater Command, Shenyang, China.
Yu CuiDepartment of Neurology, General Hospital of Northern Theater Command, Shenyang, China.
Jing QiuDepartment of Neurology, General Hospital of Northern Theater Command, Shenyang, China.
Wei LiDepartment of Neurology, General Hospital of Northern Theater Command, Shenyang, China.
Hong ZhangDepartment of Neurology, General Hospital of Fushun Mining Bureau of Liaoning Health Industry Group, Fushun, China.
Wen-Huo ChenDepartment of Neurology, Zhangzhou Municipal Hospital, Zhangzhou, China.
Li-Hua WangDepartment of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
De-Hui ZhangDepartment of Interventional Vascular Surgery, Panjin Central Hospital, Panjin, China.
Ying ChenDepartment of Interventional Vascular Surgery, Huludao Central Hospital, Huludao, China.
Yu-Tong MaDepartment of Neurology, Beipiao Central Hospital, Beipiao, China.
Zong-En GaoDepartment of Neurology, Shengli Oilfield Central Hospital, Dongying, China.
Shou-Chun WangDepartment of Neurology, The First Hospital of Jilin University, Changchun, China.
Di LiDalian Municipal Hospital, Dalian, China.
Hua LiuDepartment of Neurology, The Third People's Hospital of Chengdu, Chengdu, China.
Thanh N NguyenNeurology, Radiology, Boston Medical Centre, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2810-1685

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

EdaravoneIschemic StrokeThrombectomyAgedDouble-Blind MethodFemaleHumansMaleMiddle AgedTreatment OutcomeEdaravone

Identifiers

PMID40064868
PMCPMC11894225

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.