Evidence map›Paper›PMID 40064841›Full record

SynthesisJournal of thrombosis and thrombolysis2025

Incidence of arterial and venous thromboembolism in cancer patients- insights from more than 5,000,000 patients.

Hai-Wei Deng, Jie Li, Yuan-Sheng Zhai, Wei-Yi Mei, Xiao-Xiong Lin, Qing Xu, Qian Zheng, Jin-Sheng Chen, Zhi-Bin Huang, Xing Wu and 1 more

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Journal of thrombosis and thrombolysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hai-Wei Deng *Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan Road #2, Guangzhou, Guandong, 510080, China.
Jie Li *Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan Road #2, Guangzhou, Guandong, 510080, China.
Yuan-Sheng Zhai *Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan Road #2, Guangzhou, Guandong, 510080, China.
Wei-Yi MeiDepartment of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan Road #2, Guangzhou, Guandong, 510080, China.
Xiao-Xiong LinDepartment of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan Road #2, Guangzhou, Guandong, 510080, China.
Qing XuDepartment of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan Road #2, Guangzhou, Guandong, 510080, China.
Qian ZhengDepartment of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan Road #2, Guangzhou, Guandong, 510080, China.
Jin-Sheng ChenDepartment of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan Road #2, Guangzhou, Guandong, 510080, China.
Zhi-Bin Huang *Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan Road #2, Guangzhou, Guandong, 510080, China. hzbin2603@163.com.
Xing Wu *Department of Cardiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan Road #2, Guangzhou, Guandong, 510080, China. zswuxing@163.com.
Yun-Jiu Cheng *Department of Cardiology, Guangdong Provincial People's Hospital, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, 106 Zhongshan Road #2, Guangzhou, Guandong, 510080, China. cheng831011@sina.com.

Funding

Medical Science and Technology Research Foundation of Guangdong Province A2022050
6 · The paper itself

Abstract

The reported incidence of arterial thromboembolism (ATE) and venous thromboembolism (VTE) after cancer varies. A meta-analysis was performed to define the incidence of thromboembolism (TE) in cancer patients. Articles were searched in PubMed and Embase from inception to November 1, 2023. Studies reporting the incidence data or data from which incidence could be estimated among patients with cancer and the explicit follow-up duration were included. Seventy-four studies involving 5,059,134 cancer patients were identified. The incidence rate per 1000 person-years was 11.60 (95% CI 7.62-15.58) for ATE, 6.11 (95% CI 3.70-8.53) for myocardial infarction, 9.07 (95% CI 7.48-10.66) for ischemic stroke, 2.11 (95% CI 0.89-3.31) for another ATE, 26.32 (95% CI 24.46-28.18) for VTE, 12.69 (95% CI 11.51-13.87) for deep vein thrombosis, 5.94 (95% CI 5.29-6.59) for pulmonary embolism, and 13.18 (95% CI 9.93-16.42) for another VTE. In addition, the highest incidence of ATE was observed in patients with gastrointestinal cancer, while patients with pancreatic cancer had the highest incidence of VTE. The risk of ATE and VTE increased at the initial stage of cancer, and then declined and became non-significant. This meta-analysis provided overall estimates of ATE and VTE incidence in cancer patients, adding an important insight into the trajectory of the development of TE in cancer patients, which could help the early detection of TE in cancer patients in the future.

Indexed as

NeoplasmsThromboembolismVenous ThromboembolismHumansIncidencePulmonary EmbolismRisk FactorsArterialCancerIncidenceThromboembolismVenous

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.