Evidence map›Paper›PMID 40064840›Full record

ArticleJournal of thrombosis and thrombolysis2025

Predictors of venous thromboembolic events in hospitalized patients with COVID-19.

Giovanni Scimeca, Darsiya Krishnathasan, Sina Rashedi, Zhou Lan, Alyssa Sato, Nada Hamade, Antoine Bejjani, Candrika D Khairani, Julia Davies, Nicole Porio and 29 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of thrombosis and thrombolysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors.

Giovanni ScimecaThrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Darsiya KrishnathasanThrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Sina RashediThrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Zhou LanThrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Alyssa SatoThrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Nada HamadeThrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Antoine BejjaniThrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Candrika D KhairaniThrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Julia DaviesThrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Nicole PorioThrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Ali A AssiDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Andre ArmeroThrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Anthony TristaniThrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Marcos D Ortiz-RiosDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Victor NauffalDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Zaid AlmarzooqDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Eric WeiDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Valeria Zuluaga-SánchezThrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Mehrdad ZarghamiDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Aditya AchantaDivision of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Sirus J JesudasenDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Boston, MA, USA.
Bruce TiuThrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Geno J MerliDepartment of Cardiology, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Orly LeivaDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
John FanikosDepartment of Pharmacy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Aditya SharmaDepartment of Medicine, Cardiovascular Medicine, University of Virginia Health, Charlottesville, VA, USA.
Samantha RizzoThrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Mariana B PfefermanThrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Ruth B MorrisonThrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Alec VishnevskyDepartment of Cardiology, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Judith HsiaCPC Clinical Research, Aurora, CO, USA.
Mark R NehlerCPC Clinical Research, Aurora, CO, USA.
James WelkerAnne Arundel Research Institute, Annapolis, MD, USA.
Marc P BonacaCPC Clinical Research, Aurora, CO, USA.
Brett CarrollSmith Center for Cardiovascular Outcomes Research, Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Samuel Z GoldhaberThrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Umberto CampiaThrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Behnood BikdeliThrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Gregory PiazzaThrombosis Research Group, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. gpiazza@bwh.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

COVID-19 is associated with an increased risk of venous thromboembolism (VTE) in hospitalized patients. Although prior studies have attempted to identify predictors of VTE, restricted sample size and use of administrative claims data have limited such analyses. We utilized data from hospitalized patients in the CORONA-VTE Network, a United States multicenter registry of adult patients with PCR-confirmed COVID-19 (N = 3,844). The primary outcome was time-to-first event for a composite of adjudicated pulmonary embolism or deep vein thrombosis during 90-day follow-up. The candidate variables were selected by a priori clinical consensus. We conducted cause-specific Cox regression analysis adjusted for the selected variables for each imputed dataset and pooled the estimated HRs for reporting (p < 0.05 for significance). VTE occurred in 206 patients, with a cumulative incidence of 5.3% at 90 days. The covariates associated with increased risk of VTE were history of VTE (HR: 1.71; 95% CI: 1.11-2.63), corticosteroid therapy (HR: 1.76; 95% CI: 1.32-2.33) and known thrombophilia (HR: 3.56; 95% CI: 1.54-8.21) while therapeutic anticoagulation at baseline (HR: 0.42; 95% CI: 0.26-0.69), antecedent use of statins (HR: 0.67; 95% CI: 0.50-0.90), and prophylactic anticoagulation during hospitalization (HR: 0.52; 95% CI: 0.38-0.71) were associated with reduced risk of VTE. While prior VTE, corticosteroid therapy, and known thrombophilia were associated with an increased risk of VTE, prescriptions of prophylactic and therapeutic anticoagulation, and statins were associated with a decreased risk. Once externally validated, these findings may inform risk assessment in hospitalized patients with COVID-19.

Indexed as

COVID-19HospitalizationPulmonary EmbolismVenous ThromboembolismVenous ThrombosisAdrenal Cortex HormonesAdultAgedAnticoagulantsFemaleHumansIncidenceMaleMiddle AgedRegistriesRisk AssessmentAdrenal Cortex HormonesAnticoagulantsCoronavirusCOVID-19Deep vein thrombosisEmbolismInpatientsPulmonaryRisk factorsVenous thromboembolism

Identifiers

PMID40064840

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.