Evidence map›Paper›PMID 40064789›Full record

ArticleProbiotics and antimicrobial proteins2026

Study on the Effect of Bifidobacterium adolescentis CCFM1066 on Exercise Performance, Gut Microbiota, and Its Metabolites in Mice.

Hongchao Wang, Huizi Ma, Huimin Yan, Zhangming Pei, Jianxin Zhao, Hao Zhang, Zhijian Zhang, Wenwei Lu

Abstract read
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Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hongchao Wang *State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, Jiangsu, China.
Huizi Ma *State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, Jiangsu, China.ORCID 0009-0006-9285-0636
Huimin YanState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, Jiangsu, China.ORCID 0009-0007-3711-115X
Zhangming PeiState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, Jiangsu, China.ORCID 0000-0001-5598-9280
Jianxin ZhaoState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, Jiangsu, China.
Hao ZhangState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, Jiangsu, China.
Zhijian ZhangDepartment of Nephrology, The Affiliated Wuxi People'S Hospital of Nanjing Medical University, Wuxi People'S Hospital, Wuxi Medical Center, Nanjing Medical University, 299 Qingyang Rd, Wuxi, Jiangsu, 214000, People's Republic of China. zhangzhijian@njmu.edu.cn.
Wenwei LuState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, Jiangsu, China. luwenwei@jiangnan.edu.cn.ORCID 0000-0002-8636-9815

Funding

Cohort and Clinical Research Program of Wuxi Medical Center, Nanjing Medical University WMCC202403National Key Research and Development Program of China 2022YFF1100403National Natural Science Foundation of China 32172212, 32394052
6 · The paper itself

Abstract

Prolonged high-intensity exercise consumes significant energy, leading to fatigue and decreased performance. This study explores the effects of Bifidobacterium adolescentis CCFM1066 on exercise performance, gut microbiota, and its metabolites in mice. The results of the mouse experiments showed the mice which were intervened by Bifidobacterium adolescentis CCFM1066 have a significant increase in exercise performance, including forceful swimming time, fatigue baton turning time, and forelimb grip strength. Through metagenomic sequencing and differential metabolites, analysis indicated that the intervention of CCFM1066 increased Lachnospiraceae bacterium, Parabacteroides goldsteinii, Bacteroides xylanisolvens, and Bifidobacterium adolescentis and altered the key metabolic pathways including protein digestion and absorption and biosynthesis of amino acids. Supplementation with CCFM1066 modulates the production of short-chain fatty acids (SCFAs) and fatty acid amides (FAAs) by gut microbiota, decreasing levels of lactic acid (LA), blood urea nitrogen (BUN), lactate dehydrogenase (LDH), and creatine kinase (CK) while increasing muscle and hepatic glycogen content, thus reducing central nervous system fatigue and thereby improving exercise endurance and performance. These findings provide new insights into nutritional interventions for sports performance.

Indexed as

Bifidobacterium adolescentisGastrointestinal MicrobiomePhysical Conditioning, AnimalProbioticsAnimalsMaleMiceBifidobacterium adolescentisExercise performanceGut microbiotaMetabolitesNutritional interventions

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.