ReviewNaunyn-Schmiedeberg's archives of pharmacology2025
Research progress on the bioactivity of platycodin D from Platycodon grandifloras.
Review in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Integrated Metabolomic and Transcriptomic Analysis Suggests Potential Therapeutic Mechanism of Shengxian Decoction in Hypobaric Hypoxia-Induced Pulmonary Hypertension in SD Rats.Drug design, development and therapy · 2026Article
- Exploring the Therapeutic Role of Natural Products in Allergic Rhinitis Based on Pathophysiology and Signaling Pathways.Journal of asthma and allergy · 2025Review
- Medicinal plants and compounds for chronic bronchitis treatment: efficacy and action mechanisms.Frontiers in pharmacology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Platycodon grandiflorus, in the family Platycodonaceae, has been traditionally utilized in China to treat sore throats, hoarseness, and coughs with phlegm. As a medicinal and food plant, P. grandiflorus has a long history of use. Recent research on natural medicine has highlighted the biological activity and potential medicinal benefit of P. grandiflorus, which has prompted in-depth studies. One of the main active compounds extracted from the root of this plant is platycodin D (PD). This compound has various beneficial properties, including anti-inflammatory, antitumor, antioxidant, metabolic regulatory, antiviral, hepatoprotective, and spermatogenic effects. Additionally, PD can serve as a vaccine adjuvant to increase the efficacy of vaccines. This article explores the potential mechanism of action in treating hepatocellular carcinoma, breast cancer, lung cancer, and diabetes. The pharmacokinetics and bioavailability of PD are also discussed. With advancements in basic research and clinical applications, PD is anticipated to become a significant therapeutic agent for treating inflammatory diseases, metabolic disorders, and cancer.
Indexed as
Identifiers
40064661What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.