Evidence map›Paper›PMID 40064644›Full record

ArticleAesthetic plastic surgery2025

Safety and Efficacy Evaluation of Composite Collagen in Human Infraorbital Anti-aging and Nude Mouse Skin Photoaging.

Tao Wang, Aawrish Khan, Lunli Gong, Kim Hong, Lili Qi, Haiyan Cui

Abstract read
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In one paragraph

Article in Aesthetic plastic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Operational Standard for Tissue-Extracted Collagen Facial Injection Techniques.Clinical, cosmetic and investigational dermatology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tao Wang *Department of Plastic and Cosmetic Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, People's Republic of China.
Aawrish Khan *Department of Plastic and Cosmetic Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, People's Republic of China.
Lunli GongDepartment of Plastic and Cosmetic Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, People's Republic of China.
Kim HongDepartment of Plastic and Cosmetic Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, People's Republic of China.
Lili QiDepartment of Plastic and Cosmetic Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, People's Republic of China.
Haiyan CuiDepartment of Plastic and Cosmetic Surgery, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, People's Republic of China. u2beauty1@sina.com.ORCID 0000-0002-0879-2415

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCollagen is currently a widely used injectable filler material. Due to the complexity and specificity of the infraorbital structure and function, it undergoes various aging changes earlier in the facial aging process. Additionally, continuous exposure to Ultraviolet (UV) leads to photoaging of the skin. In this study, we utilized type I and type III composite collagen as a filler material for injecting the infraorbital region of the human face and the dorsal region of a nude mouse skin photoaging model to assess its effectiveness and safety.

objectiveTo assess the effectiveness of type I and type III composite collagen in treating age-related changes in the human infraorbital area, as well as in a nude mouse model of skin aging.

methodsA total of 36 patients with infraorbital aging were enrolled to receive type I and type III composite collagen injections. The improvement of infraorbital aging was assessed at pre-injection, immediate post-injection, 1 week, 4 weeks, and 12 weeks. Additionally, nude mice photodamaged models were prepared and collagen injections were administered to treat photodamaged skin. The therapeutic efficacy was assessed by gross view, histological staining, gene expression analysis, and ELISA assay.

resultsType I and Type III composite collagen injection can immediately fill depressed areas. However, one week after the injection, the collagen dehydrates and contracts, causing the material to be absorbed by the tissues and resulting in a slight regression of the filling effect. After one month, some of the collagen has degraded, with most of it degrading after three months. Additionally, in treating photoaging, type I and type III composite collagen has a more pronounced therapeutic effect on photoaging and demonstrates better results in collagen regeneration, inflammation reduction, and melanin control.

conclusionType I and Type III composite collagen demonstrates superior efficacy and safety in addressing infraorbital aging and photoaging in nude mice skin, making it a more favorable choice as an injection material. LEVEL OF EVIDENCE II: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors   www.springer.com/00266 .

Indexed as

CollagenCollagen Type ICollagen Type IIICosmetic TechniquesDermal FillersSkin AgingAdultAgedAnimalsFemaleHumansMaleMiceMice, NudeMiddle AgedRejuvenationCollagenCollagen Type ICollagen Type IIIDermal FillersComposite collagenMinimally invasive cosmeticSkin photoaging

Identifiers

PMID40064644

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.