Evidence map›Paper›PMID 40064607›Full record

ArticleChembiochem : a European journal of chemical biology2025

A Diazaborine Activity-Based Sensing Fluorescent Probe Reports Endogenously Produced Mitochondrial Peroxynitrite in Live Macrophages.

Jack G Haggett, G Dinesh Kumar, Michael J Melville, Chelsea G Johansen, Luke D Knudson, Nikki L Farnsworth, Dylan W Domaille

Abstract read
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jack G HaggettDepartment of Chemistry, Colorado School of Mines, 1500 Illinois St, Golden, CO, USA.
G Dinesh KumarDepartment of Chemistry, Colorado School of Mines, 1500 Illinois St, Golden, CO, USA.
Michael J MelvilleDepartment of Chemistry, Colorado School of Mines, 1500 Illinois St, Golden, CO, USA.
Chelsea G JohansenDepartment of Chemical and Biological Engineering, Colorado School of Mines, 1500 Illinois St, Golden, CO, USA.
Luke D KnudsonDepartment of Chemistry, Colorado School of Mines, 1500 Illinois St, Golden, CO, USA.
Nikki L FarnsworthDepartment of Chemical and Biological Engineering, Colorado School of Mines, 1500 Illinois St, Golden, CO, USA.
Dylan W DomailleDepartment of Chemistry, Colorado School of Mines, 1500 Illinois St, Golden, CO, USA.ORCID https://orcid.org/0000-0003-0127-7485

Funding

The Role of the Pancreas Microenvironment in Regulating Islet Function and Survival in Type 1 DiabetesR01DK137221 · NIDDK · COLORADO SCHOOL OF MINES · PI Nikki L. Farnsworth · 2024 to 2026
$1.1M
The role of the peri-islet extracellular matrix in islet function and the pathogenesis of type 1 diabetesF31DK132926 · NIDDK · COLORADO SCHOOL OF MINES · PI JOHANSEN, CHELSEA GARCIA · 2022 to 2025
$129k
American Diabetes Association 7-20-JDF-020BreakthroughT1D 3-SRA-2023-1367-S-BNational Science Foundation 2138143National Science Foundation 2238563NIDDK NIH HHS F31 DK132926NIDDK NIH HHS R01 DK137221
6 · The paper itself

Abstract

We present the synthesis, properties, and imaging applications of a new class of diazaborine-based probes (Peroxynitrite Probe-1, PNP-1) for selective peroxynitrite (ONOO

Indexed as

Boron CompoundsFluorescent DyesMacrophagesMitochondriaPeroxynitrous AcidAnimalsMiceMicroscopy, FluorescenceRAW 264.7 CellsBoron CompoundsFluorescent DyesPeroxynitrous Acidactivity-based sensingfluorescent imagingmitochondriaoxidative stressperoxynitrite

Identifiers

PMID40064607
PMCPMC13112608

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.