Evidence map›Paper›PMID 40064424›Full record

ArticleThe Journal of nutrition2025

Cross-Sectional Associations between Clinical Biochemistry and Nutritional Biomarkers and Sarcopenic Indices of Skeletal Muscle in the Baltimore Longitudinal Study of Aging.

Jamie Scott, Max Yates, Toshiko Tanaka, Luigi Ferrucci, Donnie Cameron, Ailsa A Welch

Abstract read
In one paragraph

Article in The Journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jamie ScottNorwich Medical School, University of East Anglia, Norwich, United Kingdom; Centre for Population Health Research, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, United Kingdom; Norwich Epidemiology Centre, Faculty of Medicine and Health Sciences, Population Health, University of East Anglia, Norwich, United Kingdom. Electronic address: J.Scott2@uea.ac.uk.
Max YatesNorwich Epidemiology Centre, Faculty of Medicine and Health Sciences, Population Health, University of East Anglia, Norwich, United Kingdom; Department of Rheumatology, Norfolk and Norwich University Hospital, Norwich, United Kingdom.
Toshiko TanakaTranslational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States.
Luigi FerrucciTranslational Gerontology Branch, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD, United States.
Donnie CameronNorwich Medical School, University of East Anglia, Norwich, United Kingdom; Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.
Ailsa A WelchNorwich Medical School, University of East Anglia, Norwich, United Kingdom; Centre for Population Health Research, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, United Kingdom; Norwich Epidemiology Centre, Faculty of Medicine and Health Sciences, Population Health, University of East Anglia, Norwich, United Kingdom.

Funding

Wellcome Trust 218467/Z/19/Z
6 · The paper itself

Abstract

backgroundInvestigating relationships between nutritional and clinical biochemistry biomarkers and skeletal muscle mass, strength and function (sarcopenic indices) may 1) highlight micronutrients of interest for potential preventive or treatment strategies for sarcopenia, or 2) highlight biomarkers that may be useful for identifying individuals at risk of sarcopenia.

objectivesInvestigate associations between nutritional biomarkers (vitamin D, vitamin B

methodsUsing multivariable linear regression analysis, we investigated cross-sectional associations between biomarkers and sarcopenic indices in data collected from 1761 participants (age 22-103 y) from the Baltimore Longitudinal Study of Aging.

resultsHemoglobin was positively associated with ALM (β = 0.20, P = 0.021), HGS

conclusionsThe associations found between measures of iron status and creatinine and sarcopenic indices, in males in particular, indicate potential importance for muscle health. Future longitudinal and intervention studies are warranted to confirm these findings.

Indexed as

AgingMuscle, SkeletalNutritional StatusSarcopeniaAdultAgedAged, 80 and overBaltimoreBiomarkersCross-Sectional StudiesFemaleHand StrengthHumansLongitudinal StudiesMaleMiddle AgedBiomarkersagingclinical biochemistrygrip strengthmuscle massmuscle strengthnutritionnutritional biomarkersphysical performancesarcopeniaskeletal muscle

Identifiers

PMID40064424
PMCPMC12121409

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.