ReviewCurrent opinion in neurobiology2025
Building and modifying diverse synaptic properties: Insights from Drosophila.
Review in Current opinion in neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed.
- Cell-type-resolved RNA-seq reveals molecular signatures of sexual experience inNAR genomics and bioinformatics · 2026Article
- An unexpected specialization of the active zone scaffold RIM at high release synapses.bioRxiv : the preprint server for biology · 2026Article
- Glutamate receptor composition atbioRxiv : the preprint server for biology · 2026Article
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- Nonionic signaling rapidly remodels postsynaptic DLG to induce retrograde homeostatic plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Two classes of amine/glutamate multi-transmitter neurons innervate Drosophila internal male reproductive organs.bioRxiv : the preprint server for biology · 2025Article
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Authors and funding
2 authors.
Funding
Abstract
Neuronal synapses are endowed with tremendous structural, functional, and molecular diversity, honed according to the physiological needs of the circuits in which they are embedded. This diversity, once established in development, can subsequently be further modified by plasticity. It is now widely appreciated that even closely related neurons sharing the same molecular machinery can exhibit remarkable diversity in synaptic structure, function, and plasticity. How such synaptic heterogeneity is achieved is now beginning to be elucidated in a powerful model system, the glutamatergic Drosophila neuromuscular junction (NMJ). In this review, we will first discuss recent discoveries about the structural, functional, and genetic diversity at synapses made by two closely related glutamatergic motor neurons at the Drosophila NMJ, MN-Ib and -Is. Next, we detail how inherent synaptic diversity can be subsequently modified by plasticity in response to altered synaptic growth, excess glutamate release, diminished glutamate receptor functionality, and disease. Together, these insights at the Drosophila NMJ have revealed fundamental principles about how closely related synapses are differentially sculpted in development and remodeled through plasticity to ultimately stabilize neural circuit function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.