ArticleEnvironmental health perspectives2025
A Prospective Ultrasound Study of Whole Blood Metals and Incidence of Uterine Leiomyomata.
Article in Environmental health perspectives, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A prospective study of hair dyes and uterine leiomyomata incidence in the study of environment, lifestyle, and fibroids.Fertility and sterility · 2026Article
- Metals and metal mixtures associated with the odds of uterine fibroid prevalence among African Caribbean women in the Tobago Health Study.Frontiers in reproductive health · 2026Article
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9 authors.
Funding
Abstract
backgroundUterine leiomyomata (UL), hormone-dependent neoplasms, are a major source of gynecologic morbidity. Metals are hypothesized to influence UL risk through endocrine disruption, and their effects may vary by vitamin D status.
objectiveWe estimated associations of a metal mixture with incident UL, overall and by vitamin D status.
methodsWe analyzed data from the Study of Environment, Lifestyle and Fibroids, a Detroit-area prospective cohort study of 1,693 black women 23-35 years of age. We measured concentrations of 17 metals/metalloids in whole blood and 25-hydroxyvitamin D [25(OH)D] in serum collected at baseline (2010-2012). Participants underwent ultrasonography at baseline and after 20 months to detect UL. We used Bayesian kernel machine regression to estimate adjusted associations (
resultsAmong 1,132 UL-free participants at baseline, 832 (73%) had vitamin D deficiency [25(OH)D DISCUSSION: The metal mixture was positively associated with incident UL, but the association was weak and imprecise. We observed a stronger association among vitamin D-deficient participants that was driven by cadmium and mercury. https://doi.org/10.1289/EHP15218.
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