Evidence map›Paper›PMID 40063818›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Neanderthal adaptive introgression shaped

Xixian Ma, Yan Lu, Mark Stoneking, Shuhua Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xixian MaKey Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.ORCID 0009-0008-8027-2888
Yan LuState Key Laboratory of Genetic Engineering, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Center for Evolutionary Biology, School of Life Sciences, Department of Liver Surgery and Transplantation Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China.ORCID 0000-0001-6907-0443
Mark StonekingDepartment of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig D04103, Germany.ORCID 0000-0001-9044-6679
Shuhua XuState Key Laboratory of Genetic Engineering, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Center for Evolutionary Biology, School of Life Sciences, Department of Liver Surgery and Transplantation Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China.ORCID 0000-0002-1975-1002

Funding

MOST | National Key Research and Development Program of China (NKPs) 2023YFC2605400MOST | National Natural Science Foundation of China (NSFC) 32030020 32288101shanghai science and technology commission program 23JS1410100the office of global partnerships Key Projects Development Fund
6 · The paper itself

Abstract

Positive selection at the 2q21.3 enhancer region for lactase gene (

Indexed as

Enhancer Elements, GeneticGenetic IntrogressionLactaseNeanderthalsAnimalsAsia, EasternChromosomes, Human, Pair 2DNA MethylationEast Asian PeopleHaplotypesHumansPolymorphism, Single NucleotidePromoter Regions, GeneticSelection, GeneticWhite PeopleLactaseadaptive introgressionEast Asianlactase persistenceLCTNeanderthal

Identifiers

PMID40063818
PMCPMC11929401

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.