Evidence map›Paper›PMID 40063800›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

A mechanistic basis for genetic assimilation in natural fly populations.

Gonzalo Sabarís, Bernd Schuettengruber, Giorgio L Papadopoulos, Marta Coronado-Zamora, Maximilian H Fitz-James, Josefa González, Giacomo Cavalli

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Introducing the EpGEpigenomes · 2025
    Article
  4. A mechanistic basis for genetic assimilation in natural fly populations.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Gonzalo SabarísInstitute of Human Genetics, CNRS, University of Montpellier, Montpellier 34396 cedex 5, France.ORCID 0000-0002-7797-6824
Bernd SchuettengruberInstitute of Human Genetics, CNRS, University of Montpellier, Montpellier 34396 cedex 5, France.
Giorgio L PapadopoulosInstitute of Human Genetics, CNRS, University of Montpellier, Montpellier 34396 cedex 5, France.
Marta Coronado-ZamoraInstitute of Evolutionary Biology, Agencia Estatal Consejo Superior de Investigaciones Científicas, Universitat Pompeu Fabra, Barcelona 08003, Spain.ORCID 0000-0001-9779-9661
Maximilian H Fitz-JamesInstitute of Human Genetics, CNRS, University of Montpellier, Montpellier 34396 cedex 5, France.
Josefa GonzálezInstitute of Evolutionary Biology, Agencia Estatal Consejo Superior de Investigaciones Científicas, Universitat Pompeu Fabra, Barcelona 08003, Spain.ORCID 0000-0001-9824-027X
Giacomo CavalliInstitute of Human Genetics, CNRS, University of Montpellier, Montpellier 34396 cedex 5, France.ORCID 0000-0003-3709-3469

Funding

EC | European Research Council (ERC) 788972
6 · The paper itself

Abstract

Genetic assimilation is a process by which a trait originally driven by the environment becomes independent of the initial cue and is expressed constitutively in a population. More than seven decades have passed since Waddington's pioneering demonstration of the acquisition of morphological traits through genetic assimilation, but the underlying mechanism remains unknown. Here, we address this gap by performing combined genomic analyses of Waddington's genetic assimilation experiments using the ectopic veins (EV) phenocopy in

Indexed as

DrosophilaDrosophila melanogasterAllelesAnimalsChromosome InversionDrosophila ProteinsGenetic VariationPhenotypeSelection, GeneticDrosophila Proteinsepigenetic inheritancegenetic assimilationstanding genetic variationstress-induced variationWaddington

Identifiers

PMID40063800
PMCPMC11929479

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.