ArticleInflammatory bowel diseases2025
Longitudinal Monitoring of Inflammatory Bowel Disease in Mice Using Endoscopic Optical Coherence Tomography.
Article in Inflammatory bowel diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Artifact-suppressed dual-modality OCT-fluorescence endoscopic imaging of colitis in murine models.Biomedical optics express · 2026Article
- Three-dimensional ex-vivo visualization of normal and inflamed small intestine and colonic tissue using optical coherence tomography.Scientific reports · 2026Article
- Regional and Sex-Dependent Immune Profiling Across the Colon in A Mouse Model of Ulcerative Colitis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
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7 authors.
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Abstract
backgroundInflammatory bowel disease (IBD) is one of the fastest-growing diseases globally. Nearly 5 million people are affected by IBD, with an incremental growth rate of 47.45% between 1990 and 2019. AIM AND
methodsWe aim to provide a noninvasive approach to detecting IBD with an in-house developed 1310 nm endoscopic optical coherence tomography (OCT) system. Mice with acute colitis underwent a longitudinal colon imaging process for real-time and long-run disease progression. The OCT images were processed and segmented using a computer vision image processing-based segmentation algorithm for further thickness mapping and attenuation coefficient calculations.
resultAn increase in overall colon wall thickness due to inflammation was observed, as well as a reduction in attenuation coefficient due to a change in refractive index.
conclusionComparable results with white light endoscope and histological examination suggest the clinical potential of the 1310 nm endoscopic OCT system for in vivo assessment of IBD.
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