Evidence map›Paper›PMID 40063578›Full record

ArticlePloS one2025

Designing tuberculosis elimination framework through participatory processes in Ethiopia: Results from stakeholders' discussions.

Mulatu Biru, Daniel G Datiko, Degu Jerene, Asfawesen G Yohannes, Yohannes Molla, Pedro Suarez, Wondmiu Gebrekiros, Anteneh Kassa, Yewulsew Kassie, Zewdu G Dememew

Abstract read
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mulatu BiruUSAID Eliminate TB Project, KNCV Tuberculosis Foundation, Addis Ababa, Ethiopia.
Daniel G DatikoUSAID Eliminate TB Project, Management Sciences for Health (MSH), Addis Ababa, Ethiopia.
Degu JereneKNCV Tuberculosis Foundation, The Hague, Netherlands.
Asfawesen G YohannesUSAID Eliminate TB Project, KNCV Tuberculosis Foundation, Addis Ababa, Ethiopia.
Yohannes MollaUSAID Eliminate TB Project, Management Sciences for Health (MSH), Addis Ababa, Ethiopia.
Pedro SuarezMSH, Arlington, Virginia, United States of America.ORCID https://orcid.org/0000-0001-9825-1761
Wondmiu GebrekirosUSAID Ethiopia, Development Program Specialist, Infectious Diseases Cluster, Addis Ababa, Ethiopia.
Anteneh KassaUSAID Ethiopia, Development Program Specialist, Infectious Diseases Cluster, Addis Ababa, Ethiopia.
Yewulsew KassieUSAID Ethiopia, Development Program Specialist, Infectious Diseases Cluster, Addis Ababa, Ethiopia.
Zewdu G DememewUSAID Eliminate TB Project, Management Sciences for Health (MSH), Addis Ababa, Ethiopia.ORCID https://orcid.org/0000-0002-2774-7628

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTuberculosis elimination requires implementation of multi-pronged, complex interventions, but there is limited understanding of frameworks for guiding implementation. Our aim was to explore the feasibility of applying multipronged package of TB elimination interventions guided using the Medical Research Council (MRC) framework.

methodsThis study is a component of a larger quasi-experimental study aimed at demonstrating what TB elimination interventions would entail under routine TB program conditions titled Demonstrating Multipronged and Optimized Novel Strategies to Reinforce Actions Targeted at Eliminating Tuberculosis. During its preparatory phase in February 2023, we employed a participatory action research design which involved gathering feedback and insights from TB program managers, healthcare workers and community representatives about the study interventions. The study participants were selected from three districts of Amhara, Oromia, and Southern Nations, Nationalities and Peoples Regions of Ethiopia. Two senior researchers took detailed notes during the meetings using topic guided questions. Each topic guided question was thoroughly explored until no new issues emerged. Thematic analysis was conducted to summarize the reflections of the study participants from the three sessions conducted in the three regions.

results108 participants attended the preparatory phase discussions which were summarized under five sub-themes under the main theme of "Looking for local evidence compulsory for TB elimination." These included; (1) the importance of community engagement which describes the need to include health extension workers, health development army, and other community structures to support the study, (2) government interest toward local evidence, which describes how local evidence is essential to support the TB program and address challenges, (3) homogeneity of officials' commitment across the regions which is reflected in their immense support to undertake the study and suggested working together for the study follow-up,(4) cross-cutting issues or multiple factors such as nutrition, sociocultural factors, livelihood, and housing, were considered, and (5) the importance of establishing TB treatment supporter, which describes the critical role that TB treatment supporters play in ensuring successful treatment outcomes.

conclusionsThis study highlights the importance of MRC tailored protocol development and feasibility in effective implementation. Key lessons include the need for early stakeholder engagement, streamlined communication, and proactive risk management. Strong community engagement, government commitment, and addressing social determinants were critical to TB elimination. These findings emphasize the value of a collaborative, multi-pronged approach during the adoption and implementation of the TB elimination framework.

Indexed as

Disease EradicationStakeholder ParticipationTuberculosisAdultCommunity-Based Participatory ResearchEthiopiaFemaleHumansMale

Identifiers

PMID40063578
PMCPMC11892823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.