Evidence map›Paper›PMID 40063505›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Molybdenum-Catalyzed Asymmetric Amination of α-Hydroxy Esters: Synthesis of α-Amino Acids.

Shahida Perveen, Tahir Rahman, Tariq Ali, Lingyun Wang, Junjie Zhang, Ajmal Khan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Molybdenum-Catalyzed Asymmetric Amination of α-Hydroxy Esters: Synthesis of α-Amino Acids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shahida PerveenDepartment of Chemistry, School of Chemistry, Xi'an Key Laboratory of Sustainable Energy Materials Chemistry and MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi'an Jiao Tong University, Xi'an, 710049, P. R. China.
Tahir RahmanDepartment of Chemistry, School of Chemistry, Xi'an Key Laboratory of Sustainable Energy Materials Chemistry and MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi'an Jiao Tong University, Xi'an, 710049, P. R. China.
Tariq AliDepartment of Chemistry, School of Chemistry, Xi'an Key Laboratory of Sustainable Energy Materials Chemistry and MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi'an Jiao Tong University, Xi'an, 710049, P. R. China.
Lingyun WangDepartment of Chemistry, School of Chemistry, Xi'an Key Laboratory of Sustainable Energy Materials Chemistry and MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi'an Jiao Tong University, Xi'an, 710049, P. R. China.
Junjie ZhangDepartment of Chemistry, School of Chemistry, Xi'an Key Laboratory of Sustainable Energy Materials Chemistry and MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi'an Jiao Tong University, Xi'an, 710049, P. R. China.
Ajmal KhanDepartment of Chemistry, School of Chemistry, Xi'an Key Laboratory of Sustainable Energy Materials Chemistry and MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi'an Jiao Tong University, Xi'an, 710049, P. R. China.ORCID https://orcid.org/0000-0002-2415-7534

Funding

Fundamental Research Funds for Central Universities 1191329135Xi'an Jiao Tong University 7121182002Xi'an Municipal Bureau of Science and Technology 201805056ZD7CG40
6 · The paper itself

Abstract

Unnatural α-amino acids are found in a wide variety of bioactive compounds ranging from proteins to pharmaceutical agents to materials science. As a result, the investigation of efficient and simple methods for their synthesis is a major purpose in reaction development. In this study, it is found that a catalyst based on molybdenum, an earth-abundant transition metal, can facilitate the amination of readily accessible α-hydroxy esters to afford N-protected unnatural α-amino acid esters in high yield. This simple process also enables enantioselective amination, which proceeds through cooperative catalysis of chiral molybdenum complex with chiral phosphoric acid (CPA), and complements earlier procedures to the catalytic synthesis of this important class of compounds. The obtained protected α-amino acid ester products are directly useful or further utilized for the synthesis of commercially available drugs and analogs.

Indexed as

aminationhydrogen borrowingmolybdenumunnatural α‐amino acidα‐hydroxy ester

Identifiers

PMID40063505
PMCPMC12079543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.