Evidence map›Paper›PMID 40063400›Full record

ArticleeLife2025

The asymmetric expression of HSPA2 in blastomeres governs the first embryonic cell-fate decision.

Jiayin Gao, Jiawei Wang, Shiyu Liu, Jinzhu Song, Chuanxin Zhang, Boyang Liu, Keliang Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiayin Gao *Institute of Women, Children and Reproductive Health, Shandong University, Jinan, China.ORCID https://orcid.org/0009-0001-4940-3914
Jiawei Wang *Institute of Women, Children and Reproductive Health, Shandong University, Jinan, China.ORCID https://orcid.org/0000-0003-3231-0305
Shiyu LiuInstitute of Women, Children and Reproductive Health, Shandong University, Jinan, China.ORCID https://orcid.org/0009-0006-1879-6635
Jinzhu SongInstitute of Women, Children and Reproductive Health, Shandong University, Jinan, China.
Chuanxin ZhangInstitute of Women, Children and Reproductive Health, Shandong University, Jinan, China.
Boyang LiuInstitute of Women, Children and Reproductive Health, Shandong University, Jinan, China.ORCID https://orcid.org/0000-0002-1285-4842
Keliang WuInstitute of Women, Children and Reproductive Health, Shandong University, Jinan, China.

Funding

Fundamental Research Funds for the Central Universities 2022JC006Fundamental Research Funds for the Central Universities 2023QNTD004Innovative research team of high-level local universities in Shanghai SHSMU-ZLCX20210201National Natural Science Foundation of China 32170817Shandong Provincial Natural Science Foundation 2022HWYQ-034Shandong Provincial Natural Science Foundation ZR2021QC106Taishan Scholars Program of Shandong Province tsqn202211373
6 · The paper itself

Abstract

The first cell-fate decision is the process by which cells of an embryo take on distinct lineage identities for the first time, thus representing the beginning of developmental patterning. Here, we demonstrate that the molecular chaperone heat shock protein A2 (HSPA2), a member of the 70 kDa heat shock protein (HSP70) family, is asymmetrically expressed in the late 2-cell stage of mouse embryos. The knockdown of

Indexed as

BlastomeresCell DifferentiationGene Expression Regulation, DevelopmentalHSP70 Heat-Shock ProteinsAnimalsEmbryo, MammalianGene Knockdown TechniquesMiceHSP70 Heat-Shock ProteinsCARM1developmental biologyembryofirst cell-fate decisionHSPA2inner cell massmouse

Identifiers

PMID40063400
PMCPMC11893103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.