Evidence map›Paper›PMID 40063391›Full record

ArticleJournal of psychopathology and clinical science2025

Computational modeling of reversal learning impairments in schizophrenia and bipolar disorder reveals shared failure to exploit rewards.

Angus W MacDonald, Edward Patzelt, Zeb Kurth-Nelson, Deanna M Barch, Cameron S Carter, James M Gold, J Daniel Ragland, Steven M Silverstein

Abstract read
In one paragraph

Article in Journal of psychopathology and clinical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Angus W MacDonaldDepartment of Psychology, University of Minnesota.ORCID 0000-0003-4588-931X
Edward PatzeltDepartment of Psychology, Harvard University.ORCID 0000-0002-0534-5046
Zeb Kurth-NelsonDepartment of DeepMind, University College London.
Deanna M BarchDepartment of Psychological & Brain Sciences, Psychiatry, and Radiology, Washington University in St. Louis.ORCID 0000-0003-1693-8506
Cameron S CarterDepartment of Psychiatry, University of California at Davis.
James M GoldMaryland Psychiatric Research Center.
J Daniel RaglandDepartment of Psychiatry, University of California at Davis.
Steven M SilversteinDepartment of Psychiatry, University of Rochester.ORCID 0000-0002-0699-0960

Funding

Using a computational and network neuroscience framework to study pharmacological manipulations of state representation processes in early psychosisP50MH119569 · NIMH · UNIVERSITY OF MINNESOTA · PI A DAVID REDISH, Sophia Vinogradov · 2020 to 2026
$24.5M
Cognitive Neurocomputational Task Reliability and Clinical Applications ConsortiumR01MH084840 · NIMH · WASHINGTON UNIVERSITY · PI Deanna Barch, Cameron S. Carter · 2008 to 2026
$8.5M
4/5-Cognitive Neuroscience Task Reliability & Clinical Applications ConsortiumR01MH084821 · NIMH · UNIVERSITY OF MARYLAND BALTIMORE · PI GOLD, JAMES M. · 2008 to 2023
$4.2M
2/5-Cognitive Neuroscience Task Reliability & Clinical Applications ConsortiumR01MH084826 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI CARTER, CAMERON S. · 2008 to 2023
$4.0M
5/5-Cognitive Neuroscience Task Reliability & Clinical Applications ConsortiumR01MH084861 · NIMH · UNIVERSITY OF MINNESOTA · PI MACDONALD, ANGUS W · 2008 to 2024
$3.8M
Cognitive Neurocomputational Task Reliability & Clinical Applications ConsortiumR01MH084828 · NIMH · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI SILVERSTEIN, STEVEN M · 2008 to 2024
$3.3M
NIMH NIH HHS P50 MH119569NIMH NIH HHS R01 MH084821NIMH NIH HHS R01 MH084826NIMH NIH HHS R01 MH084828NIMH NIH HHS R01 MH084840NIMH NIH HHS R01 MH084861
6 · The paper itself

Abstract

The distinction between the concepts of schizophrenia and bipolar disorder is fundamental to the Kraepelinian tradition in psychiatry. One mechanism undergirding this distinction, a difference in reward sensitivity, has been championed by a number of scholars. As part of the Cognitive Neuroscience Test Reliability and Clinical applications for Serious mental illnesses consortium, 225 participants including people with schizophrenia (

Indexed as

Bipolar DisorderPsychotic DisordersReversal LearningRewardSchizophreniaAdultComputer SimulationFemaleHumansMaleMiddle Aged

Identifiers

PMID40063391
PMCPMC11955188

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.