ReviewMolecular neurobiology2025
Exploring the Nexus: How Ferroptosis, Microglia, and Neuroinflammation Converge in Ischemic Stroke Pathogenesis.
Review in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- From Tradition to Innovation: Acupuncture Therapies Targeting Ferroptosis in Neurological Disorders.Brain and behavior · 2025Pooled it
- Astrocyte-Microglia Crosstalk in Post-Hemorrhagic Neurovascular Microenvironment: Mechanistic Nodes, Cross-Stroke Comparisons, and Therapeutic Reprogramming.Translational stroke research · 2026Review
- Neuroprotective Effects of lncRNA EPB41L4A-AS1 Against Ischemic Stroke Injury Through Regulating Microglial State Transition and Ferroptosis via miR-214-3p/GPX4 Axis.Neurochemical research · 2026Article
- G9a Targeting by miR-122 Ameliorates Ischemic Brain Injury via Enhanced Microglial Autophagy and Suppressed Ferroptosis.Neurochemical research · 2026Article
- Ferroptosis-immune crosstalk in CNS diseases: mechanisms and translational insights.Frontiers in immunology · 2026Review
- Targeting Ferroptosis to Eliminate Senescent Cells: Mechanisms and Therapeutic Potential.Aging and disease · 2025Review
- Ferroptosis in ischemic stroke: mechanisms, pathological implications, and therapeutic strategies.Frontiers in neuroscience · 2025Review
- Regional high iron deposition is linked with cognitive impairments in peritoneal dialysis: a quantitative susceptibility mapping study.Frontiers in aging neuroscience · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Ischemic stroke ranks as a leading cause of significant morbidity, mortality, and disability globally, with currently available therapeutic options remaining constrained. Prior research has elucidated that neuroinflammatory processes and pronounced microglial activation constitute critical underpinnings of ischemic stroke, precipitating neural system dysfunctions and facilitating disease exacerbation. Ferroptosis, an emergent paradigm, plays a pivotal role in this context. Defined by an iron-dependent cell death pathway, ferroptosis is distinguished by marked iron accumulation, lipid peroxidation, and the concomitant irreversible destruction of the plasma membrane, thereby contributing to the propagation of ischemic stroke through the accelerated neuronal dysfunction and aberrant microglial activation. Within this review, we initially delineate the constructs of ferroptosis, microglia, ischemic stroke, and their interconnections. Subsequently, we delve into the quintessential involvement of ferroptosis in the aberrant microglial activation associated with ischemic stroke's neuroinflammatory milieu, paving the path for the exploration of novel potential therapeutic targets against ischemic stroke.
Indexed as
Identifiers
40063316What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.