Evidence map›Paper›PMID 40063298›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2025

Impact of extended [

Edanur Topal, Bilal Kovan, Ayca İribas, Serkan Kuyumcu, Mert Basaran, Aydan Malçok Demirtaş, Oner Sanli, Yasemin Sanli

Abstract read
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Real-world evaluation of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Quantifying the Renal Impact of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  3. Could we reduce renal toxicity of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  4. PET-based risk stratification for adverse events under [European journal of nuclear medicine and molecular imaging · 2026
    Article
  5. Dosimetry of [EJNMMI research · 2026
    Article
  6. Review
  7. Frailty and [Theranostics · 2026
    Review
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Edanur TopalIstanbul Faculty of Medicine, Department of Nuclear Medicine, Istanbul University, Fatih, İstanbul, 34093, Turkey. edanur.erdem@istanbul.edu.tr.ORCID 0000-0002-9848-3156
Bilal KovanIstanbul Faculty of Medicine, Department of Nuclear Medicine, Istanbul University, Fatih, İstanbul, 34093, Turkey.ORCID 0000-0002-4431-8358
Ayca İribasDepartment of Radiation Oncology, Istanbul University, Istanbul University Oncology Institute, Fatih, İstanbul, 34093, Turkey.ORCID 0000-0002-1686-7114
Serkan KuyumcuIstanbul Faculty of Medicine, Department of Nuclear Medicine, Istanbul University, Fatih, İstanbul, 34093, Turkey.ORCID 0000-0002-1158-5361
Mert BasaranDepartment of Medical Oncology, Istanbul University, Istanbul University Oncology Institute, Fatih, İstanbul, 34093, Turkey.ORCID 0000-0001-5437-134X
Aydan Malçok DemirtaşIstanbul Faculty of Medicine, Department of Bioistatistics, Istanbul University, Fatih, İstanbul, 34093, Turkey.ORCID 0000-0002-6885-0146
Oner SanliIstanbul Faculty of Medicine, Department of Urology, Istanbul University, Fatih, İstanbul, 34093, Turkey.ORCID 0000-0001-5801-6898
Yasemin SanliIstanbul Faculty of Medicine, Department of Nuclear Medicine, Istanbul University, Fatih, İstanbul, 34093, Turkey.ORCID 0000-0002-1267-2379

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to evaluate the personalized dosimetric approach by calculating the cumulative renal absorbed dose (cRD) and assessing its impact on renal functions in patients diagnosed with metastatic castration-resistant prostate cancer who underwent four or more cycles of [

methodsThe study included 110 patients who received ≥ 4 cycles of [

resultsPearson correlation analysis reveal no significant relationship between cRD and CKD-EPI values (p >.05). No significant differences were observed between pre-treatment CKD-EPI levels and those measured after the 4th, 5th, 6th, 7th, and 8th cycles (p >.05). Among patients reaching a cRD of 23 Gy, a statistically significant difference was observed between pre- and post-treatment CKD-EPI values (p <.05). Of the 13 patients exceeding cRD of 28 Gy, five maintained CKD-EPI levels above 90 mL/min/1.73 m

conclusionDespite treatment-related declines in eGFR levels, our findings indicate that a personalized dosimetric approach may enable extended cycles of [

Indexed as

DipeptidesHeterocyclic Compounds, 1-RingKidneyLutetiumProstatic Neoplasms, Castration-ResistantRadiation DosageAgedAged, 80 and overGlomerular Filtration RateHumansMaleMiddle AgedProstate-Specific AntigenRadioisotopesRadiopharmaceuticalsRadiotherapy DosageDipeptidesHeterocyclic Compounds, 1-RingLutetiumLutetium-177PluvictoProstate-Specific AntigenPSMA-617RadioisotopesRadiopharmaceuticalsExtendedKidneyPSMATreatment

Identifiers

PMID40063298
PMCPMC12222250

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.