Evidence map›Paper›PMID 40063279›Full record

ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2025

Determination of Morphogenetic and Diurnal Variability in Phenolic and Flavonoid Content of Echinacea purpurea (L.) Moench: A Potential Source of Natural Anioxidants.

Bilge Ozcan, Nejdet Sen, Mustafa Resul Demiray, Ibrahim Bulduk, Ercument Osman Sarihan, Mehmet Ugur Yildirim

Abstract read
In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bilge OzcanFaculty of Medicine, Department of Pharmacology, Uşak University, Uşak, 64200, Turkey. bilge.ozcan@usak.edu.tr.
Nejdet SenDepartment of Chemical Engineering, Selçuk University, Konya, 42130, Turkey.
Mustafa Resul DemirayDepartment of Chemical Engineering, Selçuk University, Konya, 42130, Turkey.
Ibrahim BuldukFaculty of Engineering, Department of Chemical Engineering, Afyon Kocatepe University, Afyonkarahisar, 03200, Turkey.
Ercument Osman SarihanFaculty of Agriculture, Department of Field Crops, Uşak University, Uşak, 64200, Turkey.
Mehmet Ugur YildirimFaculty of Agriculture, Department of Field Crops, Uşak University, Uşak, 64200, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Echinacea purpurea (L.) Monech has a diverse range of phytochemicals, including flavonoids, polyphenols, phenolic acids, alkylamides, and terpenoids. Phenolic and flavonoid substances derived from the leaves and flowers have been used for treatment of illness. The aim of this study to evaluate the polyphenolic components of the flowers and leaves of E. purpurea, along with the diurnal variations and the morphological differences. Two-year-old in full bloom flowers and leaves were harvested at different times of the day (6:00 am, 9:00 am, 12:00 am, 03:00 pm, 06:00 pm, 09:00 pm). The water and methanol extracts prepared from these samples to determine total phenolic, total flavonoid and phenolic compound contents. The experiment was established in randomized complete block design with three factors and three replications. The highest total phenolic content was observed in flowers with methanol extract (157.91 ± 0.32 mg QE/g dry extract) at 09.00 a.m. Also the highest total flavonoid content was observed in leaves with methanol extract at 09.00 a.m (80.12 ± 0.16 mg QE/g dry extract). Chlorogenic acid (19.1 ± 0.83 mg/g methanol extract) and caffeic acid (13.2 ± 0.58 mg/g methanol extract) were identified as the predominant phenolic acids. The peak concentrations of these phenolic acids were observed at 6:00 a.m, followed by a gradual decline throughout the subsequent hours of the day. Findings emphasize the importance of harvesting E. purpurea at the optimal time to maximize antioxidant capacity. This study provides valuable new information on morphogenetic and diurnal variation of phenolic and flavonoid content for drug and pharmaceutical raw material production.

Indexed as

AntioxidantsCircadian RhythmEchinaceaFlavonoidsPolyphenolsFlowersPlant ExtractsPlant LeavesTime FactorsAntioxidantsFlavonoidsPlant ExtractsPolyphenolsBioperiodicityCaffeic acidChlorogenic acidDiurnal RhythmEchinaceaPhenolic AcidPlant Extracts

Identifiers

PMID40063279
PMCPMC11893669

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.