Evidence map›Paper›PMID 40063244›Full record

ArticleAnnals of hematology2025

Sickle cell disease and opioid overdose outcomes in the United States: a nationwide analysis.

Anna L Bode, Oscar F Borja-Montes, Mohammed A Quazi, Aqsa Mumtaz, Amir H Sohail, Christopher R Smith, Muhammad Rizwan Khawaja, Abu Baker Sheikh

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In one paragraph

Article in Annals of hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anna L BodeDepartment of Internal Medicine, University of New Mexico, Albuquerque, NM, USA.
Oscar F Borja-MontesDepartment of Internal Medicine, University of New Mexico, Albuquerque, NM, USA. oborjamontes@salud.unm.edu.
Mohammed A QuaziDepartment of Family and Community Health, West Virginia University, Morgantown, WV, USA.
Aqsa MumtazMontefiore St. Luke's Cornwall Hospital, Newburg, NY, USA.
Amir H SohailDepartment of Surgery, University of New Mexico, Albuquerque, NM, USA.
Christopher R SmithDepartment of Internal Medicine, University of New Mexico, Albuquerque, NM, USA.
Muhammad Rizwan KhawajaAssociate Clinical Investigator, Honor Health Research Institute, Scottsdale, AZ, USA.
Abu Baker SheikhDepartment of Internal Medicine, University of New Mexico, Albuquerque, NM, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sickle cell disease (SCD) predominantly affects individuals of African descent and is characterized by frequent painful vaso-occlusive crises, often requiring opioid management. With the opioid epidemic raising concerns about opioid overdose, this study examines in-hospital outcomes among SCD and non-SCD patients hospitalized for opioid overdose. Using the National Inpatient Sample (NIS) from 2016 to 2021, we analyzed 479,175 opioid overdose hospitalizations, including 1,315 (0.3%) with a concomitant diagnosis of SCD. Propensity score matching was used to balance demographics, comorbidities, and hospital characteristics. SCD patients were younger (45.3% aged 30-49 vs. 33.1%, p < 0.001), predominantly of African descent (92.1% vs. 14.1%, p < 0.001), and more often from lower-income households (58.4% vs. 35.2%, p < 0.001). SCD patients had lower rates of mechanical ventilation (aOR: 0.7, 95% CI: 0.6-0.9) and anoxic brain injury (aOR: 0.5, 95% CI: 0.4-0.8) but experienced longer hospital stays and higher costs. No significant differences in in-hospital mortality were observed (aOR: 0.89, 95% CI: 0.7-1.1, p = 0.34). These findings emphasize the need for a nuanced approach to managing SCD patients during opioid overdose hospitalizations, focusing on mitigating complications, addressing prolonged hospital stays and higher costs, and reducing healthcare disparities through tailored strategies informed by the unique needs of this population.

Indexed as

Analgesics, OpioidAnemia, Sickle CellOpiate OverdoseAdolescentAdultFemaleHospitalizationHospital MortalityHumansLength of StayMaleMiddle AgedUnited StatesYoung AdultAnalgesics, OpioidIn-hospital complicationsMortalityOpioid overdoseSickle cell diseaseVenous thromboembolism

Identifiers

PMID40063244
PMCPMC12031745

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.