Evidence map›Paper›PMID 40063242›Full record

ArticleArchives of toxicology2025

Replication stress: an early key event in ochratoxin a genotoxicity?

C Klotz, J Borchers, J Brode, P Lambeck, A Mally

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Oral Exposure toToxins · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

C KlotzDepartment of Toxicology, University of Würzburg, Versbacher Str. 9, 97078, Würzburg, Germany.
J BorchersDepartment of Toxicology, University of Würzburg, Versbacher Str. 9, 97078, Würzburg, Germany.
J BrodeDepartment of Toxicology, University of Würzburg, Versbacher Str. 9, 97078, Würzburg, Germany.
P LambeckDepartment of Toxicology, University of Würzburg, Versbacher Str. 9, 97078, Würzburg, Germany.
A MallyDepartment of Toxicology, University of Würzburg, Versbacher Str. 9, 97078, Würzburg, Germany. mally@toxi.uni-wuerzburg.de.ORCID http://orcid.org/0000-0002-5013-5080

Funding

Deutsche Forschungsgemeinschaft 462675411
6 · The paper itself

Abstract

Ochratoxin A (OTA), a widespread food contaminant and potent renal carcinogen in rodents, is weakly genotoxic in mammalian cells. The mechanisms underlying OTA-induced genetic damage are still poorly understood. In its recent risk assessment, the European food safety authority (EFSA) considered that the specific spectrum of mutations and chromosomal damage induced by OTA may derive from unresolved replication stress. The aim of the present work was to experimentally test the hypothesis that OTA interferes with DNA replication and to characterize the cellular response to OTA-mediated replication stress. Using the DNA fiber assay to study replication fork dynamics at single molecule resolution, a small but statistically significant global delay in replication fork progression was observed in human kidney (HK-2) cells exposed to OTA at ≥ 10 µM. OTA-mediated interference with DNA replication was confirmed by a concentration-related decrease in incorporation of the thymidine analog 5-ethynyl-2'-deoxyuridine (EdU) into newly replicating DNA in HK-2 cells arrested in late G

Indexed as

DNA DamageDNA ReplicationMutagensOchratoxinsCell LineCheckpoint Kinase 1Dose-Response Relationship, DrugHistonesHumansCheckpoint Kinase 1CHEK1 protein, humanH2AX protein, humanHistonesMutagensochratoxin AOchratoxinsCarcinogenesisDNA damageDNA replicationFood contaminantGenotoxicityOchratoxin AReplication stressγH2AX

Identifiers

PMID40063242
PMCPMC12185617

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.