Evidence map›Paper›PMID 40063240›Full record

ReviewNaunyn-Schmiedeberg's archives of pharmacology2025

The role of TLRs (microbe recognition receptor) in gastric cancer: An update.

Saade Abdalkareem Jasim, Sumaya Ayad Abdulrazzaq, H Malathi, Suhaib Iqbal, Gaurav Sanghvi, E Yulchiev, Subhashree Ray, S Sunitha, Jawad Kadhim Ahmed, Ahmed Hussein Zwamel

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In one paragraph

Review in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Saade Abdalkareem JasimMedical Laboratory Techniques Department, Al-Maarif University College, Anbar, Iraq. saade.a.j@uoa.edu.iq.
Sumaya Ayad AbdulrazzaqCenter of Desert Studies, University of Anbar, Anbar, Iraq.
H MalathiDepartment of Biotechnology and Genetics, School of Sciences, JAIN (Deemed to Be University), Bangalore, Karnataka, India.
Suhaib IqbalChandigarh Pharmacy College, Chandigarh Group of Colleges, Jhanjeri, Mohali, Punjab, 140307, India.
Gaurav SanghviDepartment of Microbiology, Faculty of Science, Marwadi University Research Center, Marwadi University, Rajkot, 360003, Gujarat, India.
E YulchievDepartment of Neurology, Fergana Medical Institute of Public Health, Fergana, Uzbekistan.
Subhashree RayDepartment of Biochemistry, IMS and SUM Hospital, Siksha 'O' Anusandhan (Deemed to Be University), Bhubaneswar, Odisha, 751003, India.
S SunithaDepartment of Chemistry, Sathyabama Institute of Science and Technology, Chennai, Tamil Nadu, India.
Jawad Kadhim AhmedDepartment of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq.
Ahmed Hussein ZwamelMedical Laboratory Technique College, the Islamic University, Najaf, Iraq.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer (GC) is the result of a convoluted series of incidents that include host genetic susceptibility, Helicobacter pylori infection, and other external influences. The emergence of many hereditary and chromatin modifications in carcinogenic and tumor-inhibiting genes results in the disruption of several molecular networks, upsetting the balance between cell proliferation and apoptosis as well as the cell cycle. Important roles are played by members of the Toll-like receptor (TLR) family in both native and adaptive immunological reactions. The owner can identify various pathogen-associated molecular patterns (PAMPs) with the TLR proteins, including DNA carrying CPG, viral RNA, and bacterial lipopolysaccharides. Moreover, the TLRs detect molecular patterns associated with danger, which have been connected to a number GC. According to different concepts, TLRs are expressed by both immunological and malignant cells. The several roles that TLRs play in GC were compiled in this review paper.

Indexed as

Stomach NeoplasmsToll-Like ReceptorsAnimalsHumansToll-Like ReceptorsGCImmune responseToll-like receptor (TLR)

Identifiers

PMID40063240

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.