ArticleJournal of epidemiology and global health2025
Epidemiological and Clinical Characteristics of Human Metapneumovirus-Associated Acute Respiratory Tract Infection Cases in the Pudong New Area, Shanghai, from 2014 to 2023.
Article in Journal of epidemiology and global health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Epidemiological and Molecular Characterization of Human Metapneumovirus (HMPV) in Children Under 14 Years of Age in Shijiazhuang City, China.Pathogens (Basel, Switzerland) · 2026Article
- A Review of Respiratory Infection Caused by the Human Metapneumovirus: Occurrence, Epidemiology, Pathogenesis, Public Health Outcomes, and Intervention Strategies.Health science reports · 2026Article
- Forging a global shield against HMPV: Uniting healthcare systems and community action to counter a silent respiratory epidemic.AIMS public health · 2026Review
- The intersection between human metapneumovirus and the respiratory microbiome.Virology journal · 2025Review
- hMPV co-infections: Distinct immunopathogenic mechanisms and clinical implications of viral and bacterial pathogenesis.Folia microbiologica · 2025Review
- Epidemiology and Burden of Human Metapneumovirus Among Italian Adults in Outpatient and Inpatient Settings, 2014-2025.Influenza and other respiratory viruses · 2025Article
- hMPV Outbreaks: Worldwide Implications of a Re-Emerging Respiratory Pathogen.Microorganisms · 2025Review
- Case Report: Human metapneumovirus infection leading to septic shock in an adult with COPD and morbid obesity.Frontiers in medicine · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundThis study characterized Human metapneumovirus (HMPV) infection epidemiology and clinical features in patients with acute respiratory infections (ARIs) in Pudong New Area, Shanghai, China, compared by pre- and post-COVID-19 periods.
methodsBetween January 2014 and December 2023, the basic and clinical information, as well as respiratory tract specimens from ARIs, were collected at 14 sentinel hospitals in Shanghai Pudong. Specimens were tested for HMPV and other respiratory pathogens. The positivity rates were analyzed by age, period (pre- and post-COVID-19), season, and case type. Clinical characteristics of HMPV-infected versus non-infected cases were compared.
results14,488 ARI patients were enrolled, with a 1.77% HMPV-positive rate (257/14,488). Among the age groups, the highest positive rate was 5.39% (11 /204) in the 6-11-month age group, and all the HMPV-positive cases in the 6-11-month-old age group were inpatients. Among the < 6 months old, 1-2 years old, 3-5 years old, 6-14 years old, 15-64 years old, and ≥ 65 years old groups, the positivity rates were 1.92% (6/313), 2.92% (23/788), 2.21% (33/1494), 1.08% (25/2311), 1.46% (94/6443) and 2.21% (65/2935), respectively. HMPV-positive patients showed higher proportions of cough (p < 0.001), runny nose (p = 0.048), and sore throat (p = 0.0175) than HMPV-negative patients in children. Compared to HMPV-negative patients, there was a significant difference in pneumonia diagnosis in both children and adults (p < 0.001, p = 0.004). Before COVID-19, HMPV infection peaks occurred mainly in February and March. In October 2023, a significant peak (4.37%, 10/229) was observed.
conclusionsYoung children and elderly individuals are at higher risk for HMPV infection, with a reversal of seasonal patterns observed post-COVID-19. Surveillance of HMPV in children and the elderly is crucial for future epidemic Preparedness.
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