ArticleVeterinary research communications2025
Alleviation of glyphosate-induced toxicity by Horseradish tree (Moringa oleifera) Leaf extract and phytase in Nile Tilapia (Oreochromis niloticus) highlighting the antioxidant, anti-inflammatory, and anti-apoptotic activities.
Article in Veterinary research communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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10 authors.
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Abstract
The danger posed by waterborne toxicity from herbicides endangers the aquatic ecosystem. Using dietary medicinal herbs is a useful approach to mitigate the effects of herbicide toxicity on aquatic animals. This study attempts to examine the consequences and potential mechanisms behind the dietary addition of horseradish tree (Moringa oleifera) leaf extract (MOLE) with the help of phytase addition to check the overall growth performance, biochemical changes, histological alteration, and gene expression in normal and after glyphosate challenge in Nile tilapia. A total number of 135 Nile tilapia fish (7.93 ± 0.03 g) were randomly assigned into three groups each in triplicate. The first group is the control group and fed basal diet; the second group supplied with MOLE (200 mg of extract/kg), and the third group was supplied with MOLE (200 mg /kg), and phytase (0.2g/ kg) for 8 weeks. After the feeding trial, each experimental group was divided into two subgroups to be unchallenged and challenged with glyphosate (30 mg/L of water). The results declared significant enhancements (P < 0.05) in Weight Gain Percent (WG%), Specific growth rate (SGR), and Protein efficiency ratio (PER) and reducing feed conversion ratio (FCR) with up-regulating hepatic gh, igf1,myogenine, intestinal ghrelin and NPY in fish groups fed MOLE and phytase compared with the control group. Moreover, improving the hepatic antioxidant capacity while down-regulating hepatic igf1bp, myostatin. Interstingly, MOLE and phytase lightened glyphosate-induced biochemical alterations, antioxidants, apoptosis, and inflammation-associated genes compared to the glyphosate-challenged group. Interestingly, UPLC-ESI-MS/MS analysis recognized 16 compounds encompasing two glucosinolates, three flavonoids, one phenolic and three alkaloids in addition to four fatty acids, a terpenoid, one phytate and an aromatic glycoside. These components might be accountable for the potential effects exerted by MOLE. Therefore, the current study suggests that dietary supplementation to MOLE and phytase can be used as substitute feed supplements in sustainable farming of Nile tilapia to defend against glyphosate challenges and enhance growth, antioxidant capacity, exerting anti-inflammatory and antiapoptotic effects under normal health conditions or post glyphosate challenge.
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