Evidence map›Paper›PMID 40063125›Full record

Trial reportEuropean journal of nutrition2025

Quercetin ingestion alters motor unit behavior and enhances improvement in muscle strength following resistance training in older adults: a randomized, double-blind, controlled trial.

Taichi Nishikawa, Ryosuke Takeda, Saeko Ueda, Kaito Igawa, Tetsuya Hirono, Masamichi Okudaira, Yukiko Mita, Toshiyuki Ohya, Kohei Watanabe

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Taichi NishikawaGraduate School of Health and Sport Sciences, Chukyo University, Toyota, Japan.ORCID http://orcid.org/0000-0002-9510-8879
Ryosuke TakedaLaboratory of Neuromuscular Biomechanics, School of Health and Sport Sciences, Chukyo University, Toyota, Japan.
Saeko UedaLaboratory of Neuromuscular Biomechanics, School of Health and Sport Sciences, Chukyo University, Toyota, Japan.
Kaito IgawaLaboratory of Neuromuscular Biomechanics, School of Health and Sport Sciences, Chukyo University, Toyota, Japan.
Tetsuya HironoLaboratory of Neuromuscular Biomechanics, School of Health and Sport Sciences, Chukyo University, Toyota, Japan.
Masamichi OkudairaLaboratory of Neuromuscular Biomechanics, School of Health and Sport Sciences, Chukyo University, Toyota, Japan.
Yukiko MitaDepartment of Human Nutrition, School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan.
Toshiyuki OhyaLaboratory for Exercise Physiology and Biomechanics, Graduate School of Health and Sport Sciences, Chukyo University, Toyota, Japan.
Kohei WatanabeLaboratory of Neuromuscular Biomechanics, School of Health and Sport Sciences, Chukyo University, Toyota, Japan. wkohei@lets.chukyo-u.ac.jp.

Funding

Japan Society for the Promotion of Science JPJSBP-82626
6 · The paper itself

Abstract

backgroundDuring resistance training, quercetin ingestion can enhance motor unit (MU) with a higher recruitment threshold in older adults.

objectiveWe investigated the effects of daily quercetin glucoside ingestion on chronic adaptations in muscle strength and MU behavior following resistance training in healthy older adults.

methodsTwenty-six older adults were randomly allocated to two groups that completed 6-week resistance training intervention with the ingestion of either placebo (PLA) or quercetin glycosides (QUE) at 200 mg/day. Maximal voluntary force (MVF) during isometric knee extension, muscle mass, and MU firing behavior during ramp task at 70%MVF were measured before (PRE) and after (POST) intervention.

resultsIn both groups, knee extensor MVF was significantly increased (both p < 0.001), and the improvement in QUE (115.1 ± 11.0%) was greater than in PLA (105.3 ± 4.8%) (p < 0.001) by the Mann-Whitney test. Muscle mass was not changed from PRE to POST in PLA or QUE (p > 0.050). At POST, firing rates of Mus with relatively moderate (recruited between 20 and 40%MVF) or higher (recruited between 20 and 40%MVF) recruitment thresholds were higher in QUE than PLA (p < 0.050). There was a significant correlation between %change in MVF and %change in firing rates of MUs with a relatively higher recruitment threshold from PRE to POST (p = 0.018, r = 0.642).

conclusionsThese results suggest that the adaptations of MUs with higher recruitment thresholds explain the greater improvement in muscle strength associated with QUE ingestion. CLINICAL TRIAL REGISTRY: UMIN000053019 ( https://rctportal.niph.go.jp/detail/um?trial_id=UMIN000053019 ).

Indexed as

Motor NeuronsMuscle StrengthQuercetinResistance TrainingAgedDouble-Blind MethodFemaleHumansMaleMiddle AgedMuscle, SkeletalQuercetinElectromyographyErgogenic aidsMotor unit decompositionNeuromuscularStrength trainingSupplementation

Identifiers

PMID40063125
PMCPMC11893712

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.